CoQ10 and link to niacin

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Fat-Soluble Nutritional Factor
Coenzyme Q10 (CoQ10) is a fat-soluble nutritional factor, similar to a vitamin. It is normally found in most cells, mainly in the energy-generating bodies called mitochondria. CoQ10 is part of the electron transport chain and therefore participates in normal cellular respiration, helping generate energy. CoQ10 is famous for promoting heart health and increasing cellular energy production. The ubiquinol form of coenzyme Q10 is considered more easily absorbed. (It may be augmented with PrimaVie® shilajit. This has been shown to increase CoQ10 absorption, promote cardiovascular health, and promote cellular energy production. In short, coQ10:

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Promotes cellular energy production, especially in the brain, liver, kidneys and heart
May contain ultra-absorbable ubiquinol CoQ10 augmented with PrimaVie® shilajit. This promotes mitochondrial CoQ10 absorption.
Provides cardiovascular and antioxidant support
Offers a way to offset the natural depletion of CoQ10 over time.
Aid to Cellular Health
CoQ10 is thus not an anticancer agent per se, but an important aid to cellular health, especially at the level of the mitochondria. There is a vast amount of research literature on CoQ10. At present, there are over 15,000 articles in PubMed on the topic, with about 900 new papers appearing each year. Over 800 papers refer to both CoQ10 and cancer. By and large, these are positive. Here are three representative quotes:

“CoQ10 supplementation reduced some of the important markers of inflammation…in patients with breast cancer.” (Iran, 2021)
(Alimohammadi M, Rahimi A, Faramarzi F, et al. Effects of coenzyme Q10 supplementation on inflammation, angiogenesis, and oxidative stress in breast cancer patients: a systematic review and meta-analysis of randomized controlled- trials. Inflammopharmacology. 2021 Jun;29(3):579-593. doi: 10.1007/s10787-021-00817-8. Epub 2021 May 18. PMID: 34008150.
“A dose of 300 milligrams per day (mg/d) of coenzyme Q10 supplementation significantly increased the antioxidant capacity and reduced the oxidative stress and inflammation levels in HCC patients after surgery.”
(Liu HT, Huang YC, Cheng SB, et al. Effects of coenzyme Q10 supplementation on antioxidant capacity and inflammation in hepatocellular carcinoma patients after surgery: a randomized, placebo-controlled trial. Nutr J. 2016 Oct 6;15(1):85. doi: 10.1186/s12937-016-0205-6. PMID: 27716246; PMCID: PMC5053088.
“An increase in DNA repair enzymes and disappearance of DNA methylation patterns attributes to reduction in tumor burden and may suggest good prognosis and efficacy of the treatment.” (India, 2008)
(Premkumar VG, Yuvaraj S, Shanthi P, et al. Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy. Br J Nutr. 2008 Dec;100(6):1179-82. doi: 10.1017/S0007114508968276. PMID: 18377693)
Bottom Line
We recommend that patients take supplemental coenzyme Q10. This is taken for its anti-aging as well as anti-cancer effects. Many people have also noted an increase in energy from taking it, which is logical, for CoQ10 works primarily on the mitochondrial “power plants” of the cell.


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