KRAS Amplification

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cancercaregiver4
Posts: 1
Joined: Mon Sep 16, 2024 9:12 pm

KRAS Amplification

Postby cancercaregiver4 » Mon Sep 16, 2024 9:17 pm

A family member has rectal cancer that has spread to their lungs and liver. It has been suggested to add Erbitux to their Folfox treatments.

Their diagnostic finding showed that they were NRAS Wildtype but their KRAS was Amplification.

Is there benefit to add Erbitux with this genetic makeup?

Thanks!

User avatar
Green Tea
Posts: 545
Joined: Mon Oct 24, 2016 10:48 am

Re: KRAS Amplification

Postby Green Tea » Wed Sep 18, 2024 1:23 am

KRAS amplification in metastatic colon cancer is associated with a history of inflammatory bowel disease and may confer resistance to anti-EGFR therapy
https://www.nature.com/articles/s41379-020-0560-x
.
https://www.mycancergenome.org/content/alteration/kras-amplification/


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