***News Stories Thread*** ONGOING Updated >>> 2022

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Caat55
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Re: ***News Stories Thread*** ONGOING 2021

Postby Caat55 » Wed Jun 23, 2021 10:19 am

Any news on a vaccine, heard it mentioned on NPR on Monday?
S
Do at 55 y.o. Female
Dx 9/26/17 RC Stage 3
Completed 33 rad. tx, xeolda 12/8/17
MRI and PET 1/18 sign. regression
Surgery 1/31/18 Ileostomy, clean margins, no lymph node involved
Port 3/1/2018
Oxaliplatin and Xeloda start 3/22/18
Last Oxaliplatin 7/5/18, 5 rounds
CT NED 9/2018
PET NED 12/18
Clear Colonoscopy 2/19, 5/20

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O Stoma Mia
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Therapeutic Cancer Vaccine Shows Promise Against Multiple Tumor Types

Postby O Stoma Mia » Sat Jun 26, 2021 2:56 am

Caat55 wrote:Any news on a vaccine, heard it mentioned on NPR on Monday?
S

Therapeutic Cancer Vaccine Shows Promise Against Multiple Tumor Types
https://www.usnews.com/news/health-news/articles/2021-04-13/therapeutic-cancer-vaccine-shows-promise-against-multiple-tumor-types
Last edited by O Stoma Mia on Sun Nov 07, 2021 7:12 am, edited 1 time in total.

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O Stoma Mia
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Colon Cancer Is Rising in Younger Adults. Do Sugary Drinks Play a Role?

Postby O Stoma Mia » Sun Aug 15, 2021 12:25 am

Colon Cancer Is Rising in Younger Adults. Do Sugary Drinks Play a Role?
https://www.nytimes.com/2021/07/05/well/eat/colon-cancer-soft-drinks-young-adults.html
As consumption of sugar-laden drinks rose in the 1980s and ’90s, so did colorectal cancer rates among younger adults, a study in nurses found.

Colon and rectal cancers are rising in younger adults, though researchers aren’t sure why. A new study of women and diet suggests that sugar-sweetened drinks may play a role.

Rates of colorectal cancer in people under 50 have increased sharply in recent years. Compared with people born around 1950, those born around 1990 have twice the risk for colon cancer and four times the risk for rectal cancer.
Last edited by O Stoma Mia on Sun Nov 07, 2021 7:12 am, edited 1 time in total.

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O Stoma Mia
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What are biomarkers of the first-line treatment for colon cancer?

Postby O Stoma Mia » Tue Sep 21, 2021 12:58 pm

What are biomarkers of the first-line treatment for colon cancer?
https://medicaltrend.org/2021/09/21/what-are-biomarkers-of-the-first-line-treatment-for-colon-cancer/
With the increasingly prominent role of targeted therapy in the treatment of advanced or mCRC disease, the NCCN expert group has expanded its recommendations on biomarker testing.

At present, for patients with mCRC, it is recommended to determine the tumor gene status of KRAS/NRAS and BRAF mutations, as well as HER2 amplification and MSI/MMR status (if not completed in the past). Although no specific method is recommended, it can be tested on individual genes or as part of an NGS group.

Beckster
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Location: New Jersey

ctDNA as a Biomarker in CRC

Postby Beckster » Thu Nov 18, 2021 6:23 pm

An overview of what is currently understood about the use of ctDNA assays to help guide treatment decisions when managing patients with colorectal cancer undergoing resection of metastases.

https://www.cancernetwork.com/view/ctdn ... ker-in-crc
57/F
DX:(CC) 10/19/16
11/4/16- Lap right hemi(cecum)
CEA- Pre Op (1.9), Pre Chemo (2.5)
Type: Adenocarcinoma
Tumor size:3.5 cm x 2.5 x 0.7 cm
Grade: G3
TNM: T3N0M0/IIA
LN: 0/24
LVI present
Surgical margins: clear
MSS
12/27/2016 - Capeox, anaphylactic
1/2/17 to 6/9/17- Xeloda
6/17,12/17,6/18,12/18,6/19,12/19,12/20,12/21 CT Scan NED :D
CEA- 6/17- 3.6, 9/17- 2.8 12/17-2.8, 3/18-3.1, 6/18-3.0, 9/18 2.8, 12/18 2.5 3/19 3.1 6/19 3.1 9/19 2.6 12/19 2.8 6/20 3.0 12/20 2.7 6/21 2.9,[color=#000000]12/21 2.7[/color]
Clear Colonoscopy 10/17, 11/19,11/21 :D

crikklekay
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Re: ***News Stories Thread*** ONGOING 2021

Postby crikklekay » Fri Mar 25, 2022 6:58 am

This isn’t in human trials yet but exciting: https://news.rice.edu/news/2022/drug-fa ... ancer-mice
Caring for DH John
Stage IIIC, Lymph nodes: 6/22
Chemo: FOLFOX (6)
12/17 ER and emergency surgery
02/18 Hospital w/MSSA infected port, PICC line inserted, chest CT scan showed septic emboli & blood clots
03/18 Hospital w/CDIFF
08/18 CT Scan Clear, NEMD
2018/2019/2021 Colonoscopy Clear
2019/2020/2021/2022 CT Scan Clear
2021 PET scan & MRI show one spot on liver
08/21 Liver surgery to remove spot, confirmed mCRC. Now Stage IV
09/21 Start Folfiri + Avastin
03/22 CEA Rise, continuing chemo

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Peregrine
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A.I. tool accurately predicts tumour regrowth in cancer patients

Postby Peregrine » Sat Apr 23, 2022 12:17 pm

A.I. tool accurately predicts tumour regrowth in cancer patients (lung cancer)

    "Doctors and scientists have developed an artificial intelligence tool that can accurately predict how likely tumours are to grow back in cancer patients after they have undergone treatment.

    The breakthrough, described as “exciting” by clinical oncologists, could revolutionise the surveillance of patients. While treatment advances in recent years have boosted survival chances, there remains a risk that the disease might come back."

https://www.theguardian.com/society/202 ... r-regrowth

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Peregrine
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The truth about supplements and who should be taking them (Video)

Postby Peregrine » Sun May 22, 2022 6:49 am

The truth about supplements and who should be taking them (VIDEO)

https://www.bbc.com/reel/video/p0c5mwdb/the-truth-about-supplements-and-who-should-be-taking-them

    "There is a lot of debate about supplements. Some health professionals claim they are essential to make up for the fact that most of us aren’t eating enough fruit and veg. Others say that supplement pills do nothing and you’re wasting your money. So what’s the truth?

    Kimberley Wilson, a psychologist with a master's degree in nutrition, looks at the truth behind what multivitamins can do for our bodies and brains and why it really matters who is taking them."
NOTE: If you want more input on anti-oxidants and whether they are good or bad for you, you can look at some of these links

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CRguy
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A few recent CRC items from Practice Update

Postby CRguy » Wed Jun 15, 2022 3:54 pm

Excerpted and quoted from https://www.practiceupdate.com/dashboard/

Associations of BMI at Different Ages With Early-Onset Colorectal Cancer

Obesity, particularly in early adulthood, increases the risk of early-onset colorectal cancer, which highlights the need for personalized screening strategies.


FOLFOXIRI Plus Bevacizumab With or Without Atezolizumab for Metastatic Colorectal Cancer

Additional prospective studies can help validate the use of upfront intensive chemotherapy to increase tumour immunogenicity and enhance the antitumour effect of atezolizumab in patients with metastatic colorectal cancer.


Postoperative ctDNA Combined With Consensus Molecular Subtypes to Improve Risk Stratification in Stage III Colon Cancers

Incorporating the use of ctDNA and CMS in stage III colon cancer risk stratification adds prognostic value. Future studies are necessary to validate their clinical utility and role in individualizing postoperative chemotherapy.



PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

This phase II trial of dostarlimab in patients with mismatch repair (MMR)–deficient locally advanced rectal cancer showed that the use of PD-1–directed therapy with dostarlimab in the neoadjuvant setting was associated with a 100% clinical complete response rate.

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Peregrine
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Food additive or carcinogen? The growing list of chemicals banned by EU but used in US

Postby Peregrine » Thu Jun 23, 2022 6:23 am

Food additive or carcinogen? The growing list of chemicals banned by EU but used in US

    EFSA scientists screened nearly 12,000 scientific publications. They were particularly interested in recent research on the “genotoxicity” of titanium dioxide nanoparticles – their ability to damage DNA and lead to cell mutations, potentially causing cancer. In animal studies, nanoparticles have been found to affect microorganisms in the gut, which could trigger diseases like intestinal and bowel inflammation and colorectal cancer.

    Reference: https://www.theguardian.com/environment ... ogen-eu-us


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