I did two rounds of FOLFOX, 4 cycles each time. The first time ALT and AST were interesting indeed. I just did a quick look at the results, and saw values as high as AST 129 and ALT 299. They may have gone higher, but that range seems right for the higher end going by memory. My medical oncologist was never too concerned, but he did hold Oxi once and that seemed to help. I remember debating whether it was the Lovenox I was taking or the Oxi, but he was pretty strong about it being the Oxi, and the values did return to normal after chemo (though there is some literature on the body “acclimating” to Lovenox, so?) I did a lot of research at the time, and overall I don’t think it was a big deal. For what it’s worth, FOLFOX reduced my rectal tumor from close to 5 cm to a nCCR.
7/19: Rectal cancer: Initially staged as IIIA, T2N1M0
Initially approx 4.25 cm, low/mid rectum, mod. well diff. adenocarcinoma
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (lots of side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; multiple biopsies negative
TAE 11/20, small amount of tumor removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
Stable in 6/28 scan.