Postby catstaff » Sat May 29, 2021 12:19 pm
I am more than skeptical of naturopaths. 20 supplements is excessive and nearly certain to cause interactions. A lot of herbals are metabolized by the same liver enzymes as drugs, which can make the blood concentration of the drugs become unpredictable. Or they interfere with the metabolization of each other. It can happen with "ordinary" plant substances as well--grapefruit contains furanocoumarins which occupy one of the CYP enzymes and interfere with the breakdown of many drugs. I admit I have looked into supplements and bought many, but mostly haven't given any to DH since I don't want to risk interactions with chemo, and I'd like some evidence they do anything in humans. Even mice trials can be misleading. (This is certainly true for would-be pharmaceuticals as well, which is why small molecules keep breaking our hearts--they may work well in cells or even mice, then fail a Phase III trial in humans.) Some mushroom extracts may have some clinical trials data that's not too unreliable. I'm not convinced of anything else. For instance, there was a real clinical trial in Korea of curcumin+folfori/bev versus folfiri/bev alone, which was completed a year ago but I can't find a writeup. One can usually find a writeup of results by googling the name of the principle investigator+trial ID and they normally write something in English. So far nothing on this one. Doesn't mean it was negative, but I'd like to know the outcome.
Plus the bioavailability of most supplements is low and unpredictable. That's one of the main issues in drugs, is getting it to the target in sufficient and standardized quantity without a lot of "collateral damage." That's nearly impossible with supplements. E.g. irinotecan is derived from a botanical, it actually did come out of traditional Chinese medicine, but it's been chemically altered to isolate and improve the active ingredient--camptothecin, the natural product, has low solubility and a lot of adverse effects.
Inflammation from a vaccine could account for the CEA rise but it may also have been nothing at all. CEA fluctuations of "normal" people isn't particularly well characterized as far as I know, and 1.1 is well within normal for nonsmokers.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-