IL-6 IL-8

Please feel free to read, share your thoughts, your stories and connect with others!
User avatar
beach sunrise
Posts: 1142
Joined: Thu Mar 05, 2020 7:14 pm

IL-6 IL-8

Postby beach sunrise » Fri Oct 25, 2024 5:46 pm

I learned something new today.
IL-6 creeped up above normal, IL-8 is high normal. These two are not only a measure of inflammation and fibrinogen control but also a measure of M1/M2 macrophages. Based on IL-6, IL-8, fibrinogen and von Willebrand Factor we can assume inbalance of M1/M2 ratio favoring more of M2 than M1 circulating. Hmmm...Always something to straighten out.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Pagola44
Posts: 420
Joined: Mon Jul 03, 2023 7:57 pm

Re: IL-6 IL-8

Postby Pagola44 » Sat Oct 26, 2024 6:13 am

It sounds like you're diving into some detailed immunology! You’re absolutely right—IL-6 and IL-8 are indeed significant markers of inflammation, and they give insights into the balance between M1 and M2 macrophages, which play opposing roles in the immune response.

The M1 macrophages are typically more pro-inflammatory and help in pathogen defense and tumor suppression, while M2 macrophages are more involved in tissue repair and wound healing but can also play roles in tumor progression if overly present. An imbalance, especially one favoring M2, could indicate a tendency towards chronic inflammation or immune suppression, which can impact various health factors.

Keeping an eye on these markers (IL-6, IL-8, fibrinogen, and von Willebrand Factor) and trying to modulate them could indeed help in achieving a balanced immune response. Diet, specific supplements, and lifestyle changes can sometimes assist in nudging the M1/M2 balance. It’s great that you’re so attuned to these aspects
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

User avatar
beach sunrise
Posts: 1142
Joined: Thu Mar 05, 2020 7:14 pm

Re: IL-6 IL-8

Postby beach sunrise » Sat Oct 26, 2024 1:09 pm

I am proud of you for your research skills.
We are not handed a manual about our individualized cancer. Therefore we have to create our own which Rp has said many many times. Do the expanded bloodwork and other tests and not take no for an answer. Life Extension has many tests you order yourself which I found was cheaper on alot of them than the insurance and co-pays SMH.
IL-6 & IL-8 are part of the chemokines. Dangerous markers.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: Google [Bot] and 11 guests