Postby Pagola44 » Sat Oct 26, 2024 6:13 am
It sounds like you're diving into some detailed immunology! You’re absolutely right—IL-6 and IL-8 are indeed significant markers of inflammation, and they give insights into the balance between M1 and M2 macrophages, which play opposing roles in the immune response.
The M1 macrophages are typically more pro-inflammatory and help in pathogen defense and tumor suppression, while M2 macrophages are more involved in tissue repair and wound healing but can also play roles in tumor progression if overly present. An imbalance, especially one favoring M2, could indicate a tendency towards chronic inflammation or immune suppression, which can impact various health factors.
Keeping an eye on these markers (IL-6, IL-8, fibrinogen, and von Willebrand Factor) and trying to modulate them could indeed help in achieving a balanced immune response. Diet, specific supplements, and lifestyle changes can sometimes assist in nudging the M1/M2 balance. It’s great that you’re so attuned to these aspects
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic