osteoarthrosis - platelet rich plasma and stem cell implant for oncologic patients?

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I_will_fight
Posts: 148
Joined: Mon Jun 29, 2020 3:38 pm

osteoarthrosis - platelet rich plasma and stem cell implant for oncologic patients?

Postby I_will_fight » Mon Mar 25, 2024 3:45 am

Hi all,

I am suffering from osteoarthritis in my left knee... I am seeking treatment and a traumatologist suggested the use of Platelet rich plasma and stem cells implants as viable treatments.

Does anyone here have experience/knowledge/papers/opinion on the use of platelet rich plasma or stem cell implant treatment for arthrosis in patients with colorectal cancer history?

The procedure basically implies taking bone marrow from your hip and implanting it in your knee. There the bone marrow cells release growth factors to repaire your damaged cartilage.

My traumatologist assures me there is no risk if the cancer is "in remission", I searched papers and no risk is apparent, but the follow up is not that long. Also there is no information of how many of the patients have cancer history.

For instance: International Orthopaedics (SICOT)
DOI 10.1007/s00264-016-3162-y

"Results A total of 3012 procedures were performed on 2372 patients with follow-up period of 2.2 years. A total of 325 adverse events were reported. The majority were pain postprocedure (n = 93, 3.9 % of the study population) and pain due to progressive degenerative joint disease (n = 90, 3.8 % of the study population). Seven cases reported neoplasms, a lower rate than in the general population. The lowest rate of adverse events was observed among patients injected with BMC (bone marrow concentrate) alone.

Conclusion Lowest rate of adverse events was among those patients receiving BMC injections alone, but the higher rate of adverse events for BMC plus adipose and cultured cells was readily explained by the nature of the therapy or the longer followup. There was no clinical evidence to suggest that treatment with MSCs of any type in this study increased the risk of neoplasm.
46 yo male Spain
06/2020 - 6cm T3N0M0 CC splenic flex
3 and 4 mm lung ground glass
lymp 0/37
dMMR MSH6
KRAS mt G13D
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beach sunrise
Posts: 1041
Joined: Thu Mar 05, 2020 7:14 pm

Re: osteoarthrosis - platelet rich plasma and stem cell implant for oncologic patients?

Postby beach sunrise » Mon Mar 25, 2024 1:29 pm

Are you in the USA? If so, I can give you a contact for a stem cell doctor, expert in this field. He has patients come to him from all over the USA. He might could give you some advice/guidance being a cancer patient NED.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
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roadrunner
Posts: 465
Joined: Sun Jan 12, 2020 8:46 pm

Re: osteoarthrosis - platelet rich plasma and stem cell implant for oncologic patients?

Postby roadrunner » Mon Mar 25, 2024 11:39 pm

One thing worth considering, in case you’re not aware. I’m wildly under-qualified to judge the importance of this factoid in this context, but platelets are believed to have a central role in facilitating metastasis. Your signature suggests that your may have confidence that a recurrence is very unlikely—not that your cancer is “in remission,” but that it is gone. There, I would think your risk would be low. If you ever reached Stage IV, however, I would be much more careful with this.

[Edited to add: I took a quick look, and while there are a number of easily located sources, they primarily relate to breast cancer (due to reconstruction), and the results are often characterized as “ambiguous.” Needless to say, the biology is way more complex than what I waved at above.]
7/19: RC: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/19-10/19 4 rds.FOLFOX neoadjuvant, 3 w/Oxiplatin (reduced 70-75%)
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ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
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VATS 12/8/21 sub-pleural met 7mm.
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6/20/22 TAE rectal polyp benign)
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