Please critique my protocol

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Pagola44
Posts: 315
Joined: Mon Jul 03, 2023 7:57 pm

Please critique my protocol

Postby Pagola44 » Thu Feb 08, 2024 11:03 pm

So i'm currently finishing my 6 months adjuvant chemotherapy. Once finished i'm thinking about this protocol would like some critique /feed back:

- Exercise 6x a week (3x Cardio / 3x Fully body weight lifting)
- Sleep aim for 7+ hours
- Fating 12-14 hours daily
- Daily consumption of tree nuts
- Daily consumption of coffee and natural decaf coffee
- Weekly consumption of fatty fish
- Limit red meat
- Daily consumption of berry smoothie (Mixed berries) + with tumeric powder
- Daily Vitamin D3 supplement
- Maintain sub 15% body fat
- Try and Eat fruit daily and vegetables daily
- Try and increase consumptions of beans and legumes
- Follow Mediterranean diet, high olive oil consumption
- Low sugar consumption, consume carbs from wholegrain foods
- edit: ip6 daily consumption supplement

Anything else to add? such as green tea?

Thanks
Last edited by Pagola44 on Thu Feb 08, 2024 11:18 pm, edited 1 time in total.
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Rock_Robster
Posts: 1017
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Please critique my protocol

Postby Rock_Robster » Thu Feb 08, 2024 11:11 pm

All looks very reasonable to me.

You might be interested in some of the studies around fasting, which suggested that ~13 hours was the point at which they saw potential impacts on cancer outcomes (studied in breast cancer). I don’t know if moving more toward a 16/8 is practical for you?

Have you given any thought to supplements and off-label medications on an ongoing basis?
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev

Pagola44
Posts: 315
Joined: Mon Jul 03, 2023 7:57 pm

Re: Please critique my protocol

Postby Pagola44 » Thu Feb 08, 2024 11:21 pm

Rock_Robster wrote:All looks very reasonable to me.

You might be interested in some of the studies around fasting, which suggested that ~13 hours was the point at which they saw potential impacts on cancer outcomes (studied in breast cancer). I don’t know if moving more toward a 16/8 is practical for you?

Have you given any thought to supplements and off-label medications on an ongoing basis?


Interesting, yea 13 would probably be better for me.

I'm still not sure if I should take daily dose aspirin or not. My oncologist said that once I receive test results from my genetic testing they will advise me. However, even so it seems to have very strong benefits in relation to cancer recurrence and outcomes.

I've also looked at other products that seem popular on here, ip6, curcumin etc i'm not sure if I should go all guns blazing and take all these supplements
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Markdale
Posts: 103
Joined: Wed Dec 02, 2020 4:45 pm

Re: Please critique my protocol

Postby Markdale » Fri Feb 09, 2024 4:55 am

What was your diet like before diagnosis? Did you exercise a lot?
09/20:Diagnosed after colonoscopy for bleeding.
MRI and ct scan confirmed tumor at rectosigmoid junction aswell as lung nodules in RLL (1X1.2cm) and RUL (3X.5cm)
10/20: LAR tumour t3n2m1 4/24 lymph nodes.
11/20: pet scan confirmed Mets
11/20: folfoxiri - 10/6/21. 12 rounds in total
1/1/21 thoracotomy 1 met removed
2/2022 sabr to 2 lung nodule
09/22 PET scan progression of sabr’d nodules
10/22 phase 1 trial bispecific antibody
9/23 added pd1 blocker
12/23 bilateral VATS all visible (7) lesions removed

Pagola44
Posts: 315
Joined: Mon Jul 03, 2023 7:57 pm

Re: Please critique my protocol

Postby Pagola44 » Fri Feb 09, 2024 5:54 am

Markdale wrote:What was your diet like before diagnosis? Did you exercise a lot?


Yes I did, i played sports several times a week and went to the gym

I didn't drink , smoke and would never eat artificial things, barely ate high sugar things like chocolate etc

Mostly ate healthy typical foods I'd eat would be oats, tuna, eggs, meat, salads etc.

I also took vitamins daily, vitmain c, vitamin b complex, bioten, collagen

Gee, makes me think maybe diet and exercise doesn't do much :/ or alternatively, maybe it did? maybe if i didn't; do those things i;d have a more advanced disease...

kinda crazy when you think about it?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Rock_Robster
Posts: 1017
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Please critique my protocol

Postby Rock_Robster » Fri Feb 09, 2024 6:32 am

Pagola44 wrote:
Rock_Robster wrote:All looks very reasonable to me.

You might be interested in some of the studies around fasting, which suggested that ~13 hours was the point at which they saw potential impacts on cancer outcomes (studied in breast cancer). I don’t know if moving more toward a 16/8 is practical for you?

Have you given any thought to supplements and off-label medications on an ongoing basis?


Interesting, yea 13 would probably be better for me.

I'm still not sure if I should take daily dose aspirin or not. My oncologist said that once I receive test results from my genetic testing they will advise me. However, even so it seems to have very strong benefits in relation to cancer recurrence and outcomes.

I've also looked at other products that seem popular on here, ip6, curcumin etc i'm not sure if I should go all guns blazing and take all these supplements


Yeah there’s a bunch of things that are fairly common amongst survivors, of course you’d need to have a look and see which you think suit you and you’re happy to be on. For me the list of things to consider would look something like the below…

Vitamin D
Curcumin
Resveratrol / ECGC
Niacinamide
Melatonin
Metformin
Aspirin
Quercetin
PSK / beta glucans

In my view vitamin D, PSK, metformin, and aspirin probably have the strongest empirical evidence base behind them. Curcumin is probably not far behind. But arguments can be made for all of the above (and many more) based on different therapeutic objectives and pathways.

You’re still in Melbourne right? If you don’t mind throwing a little cash at the problem there’s a couple of good integrative GPs at NIIM in Hawthorn that can help with this (and with prescriptions if needed). I had one consult with Prof. Avni Sali (the founder of the clinic) which was pretty intense, but you wouldn’t have to see him specifically.

https://niim.com.au/clinic

https://niim.com.au/clinic/practitioner ... -avni-sali
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev

Pagola44
Posts: 315
Joined: Mon Jul 03, 2023 7:57 pm

Re: Please critique my protocol

Postby Pagola44 » Sat Feb 10, 2024 2:33 am

Rock_Robster wrote:
Pagola44 wrote:
Rock_Robster wrote:All looks very reasonable to me.

You might be interested in some of the studies around fasting, which suggested that ~13 hours was the point at which they saw potential impacts on cancer outcomes (studied in breast cancer). I don’t know if moving more toward a 16/8 is practical for you?

Have you given any thought to supplements and off-label medications on an ongoing basis?


Interesting, yea 13 would probably be better for me.

I'm still not sure if I should take daily dose aspirin or not. My oncologist said that once I receive test results from my genetic testing they will advise me. However, even so it seems to have very strong benefits in relation to cancer recurrence and outcomes.

I've also looked at other products that seem popular on here, ip6, curcumin etc i'm not sure if I should go all guns blazing and take all these supplements


Yeah there’s a bunch of things that are fairly common amongst survivors, of course you’d need to have a look and see which you think suit you and you’re happy to be on. For me the list of things to consider would look something like the below…

Vitamin D
Curcumin
Resveratrol / ECGC
Niacinamide
Melatonin
Metformin
Aspirin
Quercetin
PSK / beta glucans

In my view vitamin D, PSK, metformin, and aspirin probably have the strongest empirical evidence base behind them. Curcumin is probably not far behind. But arguments can be made for all of the above (and many more) based on different therapeutic objectives and pathways.

You’re still in Melbourne right? If you don’t mind throwing a little cash at the problem there’s a couple of good integrative GPs at NIIM in Hawthorn that can help with this (and with prescriptions if needed). I had one consult with Prof. Avni Sali (the founder of the clinic) which was pretty intense, but you wouldn’t have to see him specifically.

https://niim.com.au/clinic

https://niim.com.au/clinic/practitioner ... -avni-sali


Great stuff, really appreciate the information,

in your opinion do you think those supplements are worth taking?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Rock_Robster
Posts: 1017
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Please critique my protocol

Postby Rock_Robster » Sat Feb 10, 2024 8:28 am

Well it’s quite personal as you need to make your own decision based on the benefits vs risks, and what you’re prepared to commit to both in terms of pill burden and financially (some of those are not particularly cheap, especially the compounded meds). But I’d say they’re all worth looking at.

For me, most of the above had very little side effects so taking them wasn’t a big deal. However metformin can cause diarrhea and make some people very gassy, resverstrol/ECGC can cause elevated liver enzymes, and melatonin can cause drowsiness or interfere with sleep patterns. So it’s really just a matter of seeing how you handle them, and how you want to spend your energy and money.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev


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