Average time on folfiri avastin

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Bianca10
Posts: 119
Joined: Thu Jun 29, 2023 4:46 pm

Average time on folfiri avastin

Postby Bianca10 » Thu Feb 01, 2024 11:00 am

How do people deal with the knowledge that folfiri Avastin only tends to work for a few months
Dreading my partners next scan.

Rock_Robster
Posts: 1017
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Average time on folfiri avastin

Postby Rock_Robster » Thu Feb 01, 2024 11:45 am

The median time to progression on FOLFIRI+Bev is more like 10 months, but that’s a pretty meaningless figure as there are a decent cohort of patients who are able to stay on it for several years (and indeed some that unfortunately progress within a few months or don’t respond at all).

The issue here is that population statistics are not predictive for your partner’s case - all you can do is try and hope that he’ll be toward the right-hand side of the curve (plus do all you reasonably can to improve the chances of that happening, and have contingency plans for if it doesn’t).

Also, always worth a re-read: https://journalofethics.ama-assn.org/ar ... ge/2013-01
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev

Bianca10
Posts: 119
Joined: Thu Jun 29, 2023 4:46 pm

Re: Average time on folfiri avastin

Postby Bianca10 » Thu Feb 01, 2024 12:23 pm

Rock_Robster wrote:The median time to progression on FOLFIRI+Bev is more like 10 months, but that’s a pretty meaningless figure as there are a decent cohort of patients who are able to stay on it for several years (and indeed some that unfortunately progress within a few months or don’t respond at all).

The issue here is that population statistics are not predictive for your partner’s case - all you can do is try and hope that he’ll be toward the right-hand side of the curve (plus do all you reasonably can to improve the chances of that happening, and have contingency plans for if it doesn’t).

Also, always worth a re-read: https://journalofethics.ama-assn.org/ar ... ge/2013-01


Thanks Rob, appreciate you. You’re always able to make me feel slightly better.

In terms of doing all we can to be on the right side of the curve, healthy eating and exercise I guess right? We try and do IV vit C as much as possible but it’s difficult as it isn’t local to us (opening hours etc are also an issue) and Chris still works.

Claudine
Posts: 808
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Average time on folfiri avastin

Postby Claudine » Mon Feb 05, 2024 1:32 pm

Well, my husband did 18 3-week cycles, and never developed resistance. He stopped it to get surgery (the point was to reduce the size of his adrenal met, and eliminate micro lung mets), and could get back on it, if need be. I must say, though, that side effects (especially fatigue) became worse towards the end of that treatment, but they were still manageable. Good luck with the scan!
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary

Tumors: L4 04/18; left adrenal gland & small lung nodules 03/19
rectum 02/22 (pT3 pN0 stage 2A); L3 09/22

Surgeries: intestinal resect. 05/18 (no cancer - Crohn's); adrenalectomy 02/20
L3-L4-L5 fusion and corpectomy 05/20; LAR 04/22; ileo reversal 09/22
L2-L3 fusion and corpectomy 09/22

Treatments: EBRT 04/18; SBRT 02/19; Failed adjuvant Xelox ; Folfiri/Avastin 03/19 - 01/20
adjuvant chemorad (Xeloda) 06/22; SBRT 11/22; Lonsurf/Avastin 12/23


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