Hi all, a few folk suggested I update when I had some info on how my new somewhat personalised protocol was going. Essentially I’m doing FOLFIRI+Bev, but modified as below:
W1: 35% irinotecan, bolus fluorouracil, leucovorin, 100% bevacivzumab
W2 35% irinotecan, bolus fluorouracil, leucovorin
W3: Off
Having now done 2 cycles of this, my CEA has halved (140 to 70), and similar on CA19.9 (400 to 200ish). LDH is down from 600 to 400, though onc reckons that will also be elevated due to my regular Neulasta use.
Am going to get a CAP CT tonight to confirm the inside matches the bloods, but overall feeling positive/hopeful. Not least because this a much more tolerable (if perhaps more inconvenient) regimen for me when compared to protocol FOLFIRI-Bev, given I also have Gilbert’s Syndrome.
Of course I still also want to qualify for trials, so now my best outcome would be that everything has shrunk, but I also need an eagle-eyed radiologist to spot one “something” new somewhere non-concerning but that meets the size criteria, so we can technically argue progression and start trial screening again…
Thanks all,
Rob