FOLFIRINOX -- Treatment and side-effects

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Peregrine
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Joined: Tue Mar 01, 2022 1:18 am

FOLFIRINOX -- Treatment and side-effects

Postby Peregrine » Wed Jan 24, 2024 9:33 am

FOLFIRINOX
    FOL – Folinic acid (i.e., leucovorin)
    F – Fluorouracil (5FU)
    IRIN – Irinotecan
    OX– Oxaliplatin.
FOLFIRINOX Overviews (U.K.):
FOLFIRINOX - Detailed dosing & side effects information for U.K patients (Important !!)
NOTE: Oxaliplatin toxicity and oxaliplatin desensitization protocols -
  • Oxaliplatin desensitization questions
    http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=35164#p246839
    .
  • Allergic reaction to Oxi
    http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=43093#p304849
    .
  • Desensitization protocol for oxaliplatin
    http://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=57906&p=456018#p456018
    .
  • Hypersensitivity Reactions to Oxaliplatin and the Application of a Desensitization Protocol
    https://pubmed.ncbi.nlm.nih.gov/15477639/
    .
  • Oxaliplatin - Slower infusion rate. Normally, the Cycle 1 infusion is run at a slower rate (like 3 hours instead of the normal 2 hour infusion). This is so that they can better monitor the patient for reactions during the first infusion. From Cycle 2 onward, however, they will probably try to set up the infusion at the normal rate (like 2 hours to deliver the same amount of chemo that was delivered over a 3-hour span in the Cycle 1 infusion). This might be too fast for you. It would be less stressful on your system if they continued with the slower infusion rate from Cycle 2 onward. The down-side to this is that your infusion sessions would be an hour or more longer than standard if you choose to go with the slower setting. This is something that you could discuss with your oncologist.
    .
  • Oxaliplatin -Lower overall dose of oxaliplatin - I think the standard dose for oxaliplatin is 85mg/m2, but the fall-back dose for patients who cannot tolerate this level is 75mg/m2. It might be better for you over the long haul if you were given the lower dose instead of the standard dose. With the lower dose you would have almost all of the benefits of oxaliplatin, but would have the added possible benefit that you may be able to tolerate oxaliplatin for the treatment period as opposed to having to drop it completely halfway through. This is also something you could discuss with your oncologist.

JP66
Posts: 21
Joined: Sun Jan 21, 2024 8:42 am
Facebook Username: joseph peck
Location: Westchester, NY

Re: FOLFIRINOX -- Treatment and side-effects

Postby JP66 » Thu Jan 25, 2024 7:26 am

Great post.

Thank you for the info. Definitely makes me more informed going into my first round of IV chemo next week.

Much appreciated!

Joe
- Male 57 y/o
- TIIIbN+M1
- Stage IV (diagnosed 10/23)
- MSI status - ?
- KRAS non-mutant
- surgery - TME planned post chemo
- Modified Neo-adjuvant Therapy (I'm not sure why they call it "modified" although my guess is the chemo is FOLFIRINOX and not FOLFOX)
- tumor 3.9 cm craniocaudal length, 7.4 cm from AV, moderately differentiated
- 01/24 completed 27 treatments radiation+Xeloda
- CEA 8,10,11/23 1.8,1.3,1.6
- dihydroxi vit D 70.9 pg/ml


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