Clinical trial thoughts

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skimom
Posts: 69
Joined: Fri Mar 17, 2023 12:24 pm
Location: Oregon USA

Clinical trial thoughts

Postby skimom » Fri Jan 19, 2024 10:01 am

Hi guys! Had some not great news on my scans yesterday. Looks like it’s spreading. New met to spleen and esophagus. Also new one to liver although other liver mets stable. Lungs continue to grow.

Sounds to me like it’s time to try something else. I looked into trials and am wondering if anyone has any thoughts on this one?

https://clinicaltrials.gov/study/NCT055 ... e=1&rank=3

I don’t qualify for the TIL one that Prayingforccr was on (boy do I miss his posts on here!) due to previous rheumatoid arthritis but mine was mild and Im hoping there will be something I do qualify for. maybe this one?

Anyway, thanks in advance for any input you may have and best wishes on your journey through this :)
47yo F at DX
DX 12/11/22 Stage IV (liver & lung mets) KRAS PIK3CA
12/15/22 Primary tumor removed from Transverse Colon (4.3x4.0x0.6cm G2 3/15 lymph nodes. Clear margins)
01/06/23 started Folfox (10 cycles)
Initial CEA 5608
CEA after 4 rounds 1319
CEA after 6 rounds 427
CEA after 9 rounds 95
HAI pump installed 06/20/23
Start FOLFIRI and FUDR 07/05/23
CEA down to 37
31
21
18
9/2023 Switch back to FOLFOX due to new lung nodules
11/23 FOLFOX fail CEA up to 62

Quest*39
Posts: 1
Joined: Wed Jan 24, 2024 11:03 am

Re: Histotripsy

Postby Quest*39 » Tue Feb 13, 2024 3:51 pm

Hello Skimom,
Just joining. Don't even know how to list stats yet. Just read your post on Histotripsy.
My son 39, diagnosed 6-23 is my reason for joining. We're in MI
where this was developed at U of M. I've contacted them and he has a zoom scheduled later in the month for eligibility after they receive scans and all info.from HF. With 95% success rate, sounds like a worthy alternative. They just received the equipment last week. He had 10-15 in liver upon diagnosis which after 12 cycles of 5-FU 3 day pump and MVASI, oxaliplatin, Leucovorin and Irinotecan infusion every 2 weeks. Now in January Cat Scan largest are now at 2.1 and 2.0cm from 4.7, the others are not measured.

Information I received are tumors cannot be more the 5cm and fewer than 6 inside and or/ fewer that 3 outside the liver under 1.5cm.
his largest are now at 2.1 and 2.0 from 4.7, the others are not measured. According to the limits they cannot be more than 5cm and fewer than 6 inside and/or fewer than 3 outside the liver under 1.5cm.


He's getting infusion of MVASI double or triple dose every three weeks and oral capecitabine for 2 weeks daily.

Hoping and prayers for the best for you and all on this forum.

User avatar
beach sunrise
Posts: 1023
Joined: Thu Mar 05, 2020 7:14 pm

Re: Clinical trial thoughts

Postby beach sunrise » Sat Feb 17, 2024 11:58 am

Hi skimom, from what I have been reading and watching on youtube about histotropsy is that if liver or ther approved organs are targeted that for now thought is it generates a huge immune response (a wake up call to reconize) to go after other mets such as lungs. I watched a video about it and they are trying to nail down how to get lung mets with the procedure but no luck yet.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test


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