How many of you take daily dose aspirin?

[Pagola44]

Any thoughts on this ?

It seems beneficial however bit worried about bleeding/brain bleeding

[CRguy]

You may wish to review the following article, included in my recent addition to ***News Stories Thread*** ONGOING Updated >>> 2023 November <<<

Aspirin Use Tied to Lower Risk for Early Colorectal Cancer

I have used 81mg ASA (daily aspirin) as adjunct medication in the cardiovascular and colorectal cancer setting since 2007.
Prior to any surgical procedures I will adhere to surgical contraindications regarding any anticoagulants, and have had no issues.

CRguy

[Pagola44]

You may wish to review the following article, included in my recent addition to ***News Stories Thread*** ONGOING Updated >>> 2023 November <<<

Aspirin Use Tied to Lower Risk for Early Colorectal Cancer

I have used 81mg ASA (daily aspirin) as adjunct medication in the cardiovascular and colorectal cancer setting since 2007.
Prior to any surgical procedures I will adhere to surgical contraindications regarding any anticoagulants, and have had no issues.

CRguy

You're not concerned with bleeding issues?

Daily aspirin increases brain bleeds: Study
https://www1.racgp.org.au/newsgp/clinic ... eeds-study

Daily Low Dose Aspirin May Increase Risk of Brain Bleeding. What to Know
https://www.healthline.com/health-news/ ... at-to-know

Low dose aspirin increases brain bleeding risk but does not decrease stroke risk
https://jamanetwork.com/journals/jamane ... le/2807630

[rp1954]

I've taken low dose aspirin since the 1980s since there are at least two prior generations of fatal colon cancer in my lineage. Also early large polyps in a sibling, 6 at 35 yo. Also 3-4 generations of early heart attacks in the guys across the male lines, late 40s-60s.

In the 1980s, I found I could fix a lot of cardio signs and symptoms with niacin and magnesium buffered aspirin. Turned out, excess inflammation and calcium are bad and I needed even more vitamin C, D3 and magnesium because of depletion (and less excess calcium). Niacin is an anti-inflammatory for 1-2 major cytokines and in a pinch could drop my total cholesterol and raise my HDL dramatically.

As for bleeds, I don't expect much medical support in the generics category but am willing to let it go at "avoid inflammation and ulcers", use collagen forming supplements that may help strength blood vessels, maintain vascular integrity to prevent lesions and to stabilize them, and help deposit calcium in the bones rather than the blood vessels, to support the aspirin.

[Pagola44]

I've taken low dose aspirin since the 1980s since there are at least two prior generations of fatal colon cancer in my lineage. Also early large polyps in a sibling, 6 at 35 yo. Also 3-4 generations of early heart attacks in the guys across the male lines, late 40s-60s.

In the 1980s, I found I could fix a lot of cardio signs and symptoms with niacin and magnesium buffered aspirin. Turned out, excess inflammation and calcium are bad and I needed even more vitamin C, D3 and magnesium because of depletion (and less excess calcium). Niacin is an anti-inflammatory for 1-2 major cytokines and in a pinch could drop my total cholesterol and raise my HDL dramatically.

As for bleeds, I don't expect much medical support in the generics category but am willing to let it go at "avoid inflammation and ulcers", use collagen forming supplements that may help strength blood vessels, maintain vascular integrity to prevent lesions and to stabilize them, and help deposit calcium in the bones rather than the blood vessels, to support the aspirin.

Yea that's fair enough

I just wonder if I should..my oncologist advised me to do genetic testing and that they would recommend It based on the tests

But even so I just think it's better than not taking it...hmm

[DarknessEmbraced]

My GI put me on a daily low dose coated aspirin in 2018 to try to prevent ischemic colitis attacks. Unfortunately, it doesn't prevent ischemic colitis attacks but I don't see the harm in taking it.

[Green Tea]

... I just wonder if I should..my oncologist advised me to do genetic testing and that they would recommend It based on the tests

But even so I just think it's better than not taking it...hmm

Where do you stand with respect to getting genetic testing done? Have you taken your oncologist's advice to do genetic testing?

Have you taken Rock_Robster's advice to have free genetic testing done locally at VCCC & Peter Mac hospital?
https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=66552&p=515707&hilit=genetic#p515704
.
Like your oncologist has suggested, if you have results from a comprehensive genetic testing you could check to see if you have any genetic disorders related to bleeding:

https://www.genome.gov/For-Patients-and-Families/Genetic-Disorders

[Pagola44]

... I just wonder if I should..my oncologist advised me to do genetic testing and that they would recommend It based on the tests

But even so I just think it's better than not taking it...hmm

Where do you stand with respect to getting genetic testing done? Have you taken your oncologist's advice to do genetic testing?

Have you taken Rock_Robster's advice to have free genetic testing done locally at VCCC & Peter Mac hospital?
https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=66552&p=515707&hilit=genetic#p515704
.
Like your oncologist has suggested, if you have results from a comprehensive genetic testing you could check to see if you have any genetic disorders related to bleeding:

https://www.genome.gov/For-Patients-and-Families/Genetic-Disorders

Yep happened to get it done today.

They said it will take months to get results.

Interesting thanks.

Like I said I just wonder if it's worth taking as a "low risk" stage 3 person for extra coverage.

From my research it seems that the guidelines are they recommend aspirin as per the genetic testing
But why not take it otherwise ?

[I_will_fight]

I've taken low dose aspirin since the 1980s since there are at least two prior generations of fatal colon cancer in my lineage. Also early large polyps in a sibling, 6 at 35 yo. Also 3-4 generations of early heart attacks in the guys across the male lines, late 40s-60s.

In the 1980s, I found I could fix a lot of cardio signs and symptoms with niacin and magnesium buffered aspirin. Turned out, excess inflammation and calcium are bad and I needed even more vitamin C, D3 and magnesium because of depletion (and less excess calcium). Niacin is an anti-inflammatory for 1-2 major cytokines and in a pinch could drop my total cholesterol and raise my HDL dramatically.

As for bleeds, I don't expect much medical support in the generics category but am willing to let it go at "avoid inflammation and ulcers", use collagen forming supplements that may help strength blood vessels, maintain vascular integrity to prevent lesions and to stabilize them, and help deposit calcium in the bones rather than the blood vessels, to support the aspirin.

Thanks rp1954

I read that K2 vitamin helps exactly with this : "help deposit calcium in the bones rather than the blood vessels" and it should be taken together with vitamin D3, and then regular monitoring of 25-OH and Calcium levels in blood.. Does this approach make sense to you? It now seems that every supplement maker will try to sell you the D3+K2 combo.

It seems that you are achieving the same results with niacin and collagen?

Best regards

[rp1954]

I've taken low dose aspirin since the 1980s n (and less excess calcium). Niacin is an anti-inflammatory for 1-2 major cytokines and in a pinch could drop my total cholesterol and raise my HDL dramatically.
use collagen forming supplements that may help strength blood vessels, maintain vascular integrity to prevent lesions and to stabilize them, and help deposit calcium in the bones rather than the blood vessels, to support the aspirin.

Thanks rp1954

I read that K2 vitamin helps exactly with this : "help deposit calcium in the bones rather than the blood vessels" and it should be taken together with vitamin D3, and then regular monitoring of 25-OH and Calcium levels in blood.. Does this approach make sense to you? It now seems that every supplement maker will try to sell you the D3+K2 combo.
It seems that you are achieving the same results with niacin and collagen?

We have used magnesium + vitamin K2 and D3 supplementation, more customized, -able hand loaded anti-cancer, collagen formation, calcium control and bone deposition.

Niacin attacks some kinds of inflammation and often reduces bad forms of LDL and triglycerides while raising HDL substantially - much better than average for me. Early megavitamin B and C pioneer, Abram Hoffer found it useful for many cancer and mentally ill patients, perhaps related to the particular forms of inflammation reduced. We typically buy scored 500 mg tablets (x 1000 tablets, ca $24- $26), easy to break for ca 250 mg doses or even 100-125 mg for initial adaptation

Vitamin C, K2 and glucosamine help form collagen, a long with other trace minerals.
Vitamin K2 is typically marketed as menaquinone-4 (aka MK4 or menatetrenone) or menaquinone-7 (MK7). MK4 has lower oral absorption/retention (perhaps implies more doses per day, 2-3 doses) but superior cellular transport with an MK4 human transporter protein. MK4 is where most of the earlier anti-cancer, collagen formation, and anti- osteoporosis related work was done in a dose range of 15-60 mg, with the common Japanese prescription dose as 45 mg/day, for presumably smaller BSA people. Some supplement vendor literature emphasizes MK7's absorption or retention (one-a-day nutrition?), but I am more concerned about therapeutic performance in heavy duty situations, since MK7 draws on your body's (limited?) ability and resources to convert MK7 to endogenously generated MK4, presumably at limited rates/amounts.

[nmorgen]

What brand of mk4 do you use? I have found it almost impossible to find.

[rp1954]

What brand of mk4 do you use? I have found it almost impossible to find.

Yes the market offerings in the US for vK2 pills over 5 mg of menatetrenone(MK4) seem to have reduced by at least two vitamin brand sources, perhaps squeezed by a single(?) primary supplier in China and generic supplement competition in the US.

The brands that I am aware of still offering MK4 bottles around the original Japanese therapeutic dose levels are, a 15 mg MK4 cap by AOR, and two bone formulas by Nutritional Biochemistry, Inc (NBI). We used NBI's original bone formula in 2010 for 7 months, before and during 5FU chemo. Then we switched to less expensive straight 15 mg MK4 pills without the extra calcium, magnesium and vit D3, and also handloads from bulk MK4.

Our average vitamin K2 mail order cost has now risen from $25 for 90 caps x 15 mg of MK4 (best VRP price on ~4 bottle sales of their Ultra K2 ca 2013-15, but their MK4 is now a discontinued line), to about $45 for the same size from AOR's Peak K2 version.