Thoughts on taking p6 + inositol during folfox?

[Pagola44]

any thoughts on using this supplement during folfox?

[Pagola44]

all my research says its a good thing
any chance it could have adverse affects or reduce folfox affect?

[Pagola44]

anyone?

[Pagola44]

might just risk it and keep taking it

[Pagola44]

Bump

[Pagola44]

There's nothing I found that would make folfox less effective but just seeking reassurance?

[Pagola44]

suprised no one here has taken ip6/inositol during folfox?

[beach sunrise]

I had no experience with the combo.
If all you are researching is mostly beneficial then weigh it and let us know what you decide.

[Pagola44]

I had no experience with the combo.
If all you are researching is mostly beneficial then weigh it and let us know what you decide.

surprised you don't know more about ip6? you seem to know a lot about supps

ive taken it a bit during my last 2 infusions

seems to help with sides.. but just concerned it will have some negative interaction with folfox, although there's no evidence i have found of this.

[beach sunrise]

I had to educate myself and find help outside of SOC. During intial folfox I was told don't even take a vitamin d supplement. Ya, my first onc tried to kill me. I ran as fast as I could from Dr. Frankenstein and never looked back.

[CoolHandLuke8723]

Don't even take a Vitamin D Supplement? Just saw this - don't know if it applicable...
"New research suggests a simple, inexpensive option for reducing a major chemotherapy side effect (Vitamin D before chemo)
New research suggests that patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.

According to an analysis of 1,191 patients with early-stage breast cancer—using data collected in the SWOG S0221 study—20.7% of patients with vitamin D deficiency experienced at least a grade 3 level of chemotherapy-induced peripheral neuropathy (CIPN), compared to 14.2% of those with sufficient vitamin D levels. The researchers also found that inducing vitamin D deficiency in an accompanying mice model study caused neurotoxicity-like symptoms.

"These results suggest that vitamin D supplementation in patients with lower levels of vitamin D may reduce peripheral neuropathy, and particularly high grade peripheral neuropathy, which would improve these patients' long-term quality of life," explained Daniel L. Hertz, PharmD, Ph.D. "There are barely any negative consequences that come from taking steps to increase vitamin D levels. Patients can easily take safe, inexpensive, and widely available over-the-counter supplements."

Dr. Hertz explained that CIPN is a common side effect of paclitaxel and several other commonly used anticancer drugs. It typically appears as numbness, tingling, and sometimes burning pain in the fingers and toes. CIPN can eventually lead to the loss of sensation in hands and feet. These symptoms are largely untreatable and can sometimes be permanent, so it is critical that patients and oncology health care providers monitor for CIPN during treatment to address the development of treatment-related peripheral neuropathy before symptoms become intolerable . . . "
https://medicalxpress.com/news/2023-11- ... erapy.html

I take the Walmart Vitamin D gummies with various fruit flavors - tastes like candy. Price was about $9 per bottle. Usually take between 5 and 10 daily with a meal.

[Pagola44]

Don't even take a Vitamin D Supplement? Just saw this - don't know if it applicable...
"New research suggests a simple, inexpensive option for reducing a major chemotherapy side effect (Vitamin D before chemo)
New research suggests that patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.

According to an analysis of 1,191 patients with early-stage breast cancer—using data collected in the SWOG S0221 study—20.7% of patients with vitamin D deficiency experienced at least a grade 3 level of chemotherapy-induced peripheral neuropathy (CIPN), compared to 14.2% of those with sufficient vitamin D levels. The researchers also found that inducing vitamin D deficiency in an accompanying mice model study caused neurotoxicity-like symptoms.

"These results suggest that vitamin D supplementation in patients with lower levels of vitamin D may reduce peripheral neuropathy, and particularly high grade peripheral neuropathy, which would improve these patients' long-term quality of life," explained Daniel L. Hertz, PharmD, Ph.D. "There are barely any negative consequences that come from taking steps to increase vitamin D levels. Patients can easily take safe, inexpensive, and widely available over-the-counter supplements."

Dr. Hertz explained that CIPN is a common side effect of paclitaxel and several other commonly used anticancer drugs. It typically appears as numbness, tingling, and sometimes burning pain in the fingers and toes. CIPN can eventually lead to the loss of sensation in hands and feet. These symptoms are largely untreatable and can sometimes be permanent, so it is critical that patients and oncology health care providers monitor for CIPN during treatment to address the development of treatment-related peripheral neuropathy before symptoms become intolerable . . . "
https://medicalxpress.com/news/2023-11- ... erapy.html

Yea vitamin D is good with chemo