Thoughts on taking p6 + inositol during folfox?

Please feel free to read, share your thoughts, your stories and connect with others!
Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Tue Nov 14, 2023 1:18 am

any thoughts on using this supplement during folfox?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Tue Nov 14, 2023 4:03 am

all my research says its a good thing
any chance it could have adverse affects or reduce folfox affect?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Wed Nov 15, 2023 1:47 am

anyone?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Wed Nov 15, 2023 9:55 pm

might just risk it and keep taking it
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Thu Nov 16, 2023 6:36 pm

Bump
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Thu Nov 16, 2023 7:19 pm

There's nothing I found that would make folfox less effective but just seeking reassurance?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Thu Nov 16, 2023 8:44 pm

suprised no one here has taken ip6/inositol during folfox?
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

User avatar
beach sunrise
Posts: 1080
Joined: Thu Mar 05, 2020 7:14 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby beach sunrise » Fri Nov 17, 2023 12:09 am

I had no experience with the combo.
If all you are researching is mostly beneficial then weigh it and let us know what you decide.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Fri Nov 17, 2023 2:01 am

beach sunrise wrote:I had no experience with the combo.
If all you are researching is mostly beneficial then weigh it and let us know what you decide.


surprised you don't know more about ip6? you seem to know a lot about supps

ive taken it a bit during my last 2 infusions

seems to help with sides.. but just concerned it will have some negative interaction with folfox, although there's no evidence i have found of this.
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic

User avatar
beach sunrise
Posts: 1080
Joined: Thu Mar 05, 2020 7:14 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby beach sunrise » Fri Nov 17, 2023 4:02 pm

I had to educate myself and find help outside of SOC. During intial folfox I was told don't even take a vitamin d supplement. Ya, my first onc tried to kill me. I ran as fast as I could from Dr. Frankenstein and never looked back.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

CoolHandLuke8723
Posts: 109
Joined: Fri Aug 11, 2023 1:10 am
Facebook Username: CoolHandLukeNone

Re: Thoughts on taking p6 + inositol during folfox?

Postby CoolHandLuke8723 » Fri Nov 17, 2023 6:02 pm

Don't even take a Vitamin D Supplement? Just saw this - don't know if it applicable...
"New research suggests a simple, inexpensive option for reducing a major chemotherapy side effect (Vitamin D before chemo)
New research suggests that patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.

According to an analysis of 1,191 patients with early-stage breast cancer—using data collected in the SWOG S0221 study—20.7% of patients with vitamin D deficiency experienced at least a grade 3 level of chemotherapy-induced peripheral neuropathy (CIPN), compared to 14.2% of those with sufficient vitamin D levels. The researchers also found that inducing vitamin D deficiency in an accompanying mice model study caused neurotoxicity-like symptoms.

"These results suggest that vitamin D supplementation in patients with lower levels of vitamin D may reduce peripheral neuropathy, and particularly high grade peripheral neuropathy, which would improve these patients' long-term quality of life," explained Daniel L. Hertz, PharmD, Ph.D. "There are barely any negative consequences that come from taking steps to increase vitamin D levels. Patients can easily take safe, inexpensive, and widely available over-the-counter supplements."

Dr. Hertz explained that CIPN is a common side effect of paclitaxel and several other commonly used anticancer drugs. It typically appears as numbness, tingling, and sometimes burning pain in the fingers and toes. CIPN can eventually lead to the loss of sensation in hands and feet. These symptoms are largely untreatable and can sometimes be permanent, so it is critical that patients and oncology health care providers monitor for CIPN during treatment to address the development of treatment-related peripheral neuropathy before symptoms become intolerable . . . "
https://medicalxpress.com/news/2023-11- ... erapy.html

I take the Walmart Vitamin D gummies with various fruit flavors - tastes like candy. Price was about $9 per bottle. Usually take between 5 and 10 daily with a meal.
Last edited by CoolHandLuke8723 on Sat Nov 18, 2023 5:57 am, edited 1 time in total.

Pagola44
Posts: 374
Joined: Mon Jul 03, 2023 7:57 pm

Re: Thoughts on taking p6 + inositol during folfox?

Postby Pagola44 » Fri Nov 17, 2023 8:42 pm

CoolHandLuke8723 wrote:Don't even take a Vitamin D Supplement? Just saw this - don't know if it applicable...
"New research suggests a simple, inexpensive option for reducing a major chemotherapy side effect (Vitamin D before chemo)
New research suggests that patients who have insufficient levels of vitamin D before starting paclitaxel treatment are more likely to experience peripheral neuropathy.

According to an analysis of 1,191 patients with early-stage breast cancer—using data collected in the SWOG S0221 study—20.7% of patients with vitamin D deficiency experienced at least a grade 3 level of chemotherapy-induced peripheral neuropathy (CIPN), compared to 14.2% of those with sufficient vitamin D levels. The researchers also found that inducing vitamin D deficiency in an accompanying mice model study caused neurotoxicity-like symptoms.

"These results suggest that vitamin D supplementation in patients with lower levels of vitamin D may reduce peripheral neuropathy, and particularly high grade peripheral neuropathy, which would improve these patients' long-term quality of life," explained Daniel L. Hertz, PharmD, Ph.D. "There are barely any negative consequences that come from taking steps to increase vitamin D levels. Patients can easily take safe, inexpensive, and widely available over-the-counter supplements."

Dr. Hertz explained that CIPN is a common side effect of paclitaxel and several other commonly used anticancer drugs. It typically appears as numbness, tingling, and sometimes burning pain in the fingers and toes. CIPN can eventually lead to the loss of sensation in hands and feet. These symptoms are largely untreatable and can sometimes be permanent, so it is critical that patients and oncology health care providers monitor for CIPN during treatment to address the development of treatment-related peripheral neuropathy before symptoms become intolerable . . . "
https://medicalxpress.com/news/2023-11- ... erapy.html


Yea vitamin D is good with chemo
29m Male.
DX: CC, Right Hepatic Flexure, 4cm, T3, G2, M0
Stage III3B , Positive lymph nodes: (2/20)
Baseline CEA value: 1.98
LVI and PNI: absent
Surgical margins: clear
No lynch Syndrome or MSI
Primary surgery type: Laparascopic


Return to “Colon Talk - Colon cancer (colorectal cancer) support forum”



Who is online

Users browsing this forum: No registered users and 116 guests