Question on Irinotecan, 5FU, and Avastin experience

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behconsult
Posts: 264
Joined: Fri Jul 04, 2014 4:53 pm

Question on Irinotecan, 5FU, and Avastin experience

Postby behconsult » Sat Jun 03, 2023 2:45 pm

Hello Everyone, Peace be with you! I am getting put on Irinotecan, 5FU, and Avastin in a couple weeks. Can anyone share their experiences on this? Did it shrink tumors/lesions? Did you tolerate it well? I know everyone is different in their experiences. I am hoping that my functioning does drop off too much.

BTW for those with Braf V600e, I am over 9 years out since diagnosis. So keep hoping and thriving!

Thank you for any experiences you care to share.

PS: My signature line is not up to date. Bob
Stage 4 Age 56 BrafV660E 5/14
spot on perit/ Right side tumor
Resctn 6/9/2014
Folfox strt 7/2014. 6 of 12 tx
Chemo induced DM2
Pet 4 mets to lung (1 cm, 6 mm) Xeloda/Avastin 9/16 to present.
Cryo-ablation to four spots- Collapsed lung/chest tube 2x
Possible local recurrence in a spot or two on PET. Stable CT

Nor Cal
Posts: 89
Joined: Sun Dec 06, 2020 8:18 pm

Re: Question on Irinotecan, 5FU, and Avastin experience

Postby Nor Cal » Sun Jun 04, 2023 3:38 pm

Hi Bob -

As far as tolerance goes, I had to be careful with the Avastin, developing several superficial blood clots. So something to be aware of. Otherwise it was pretty standard, a few rough days, then a good week, and then it was time to start again. I worked full time while on that regimen, so obviously not too terrible. I'm currently on a 3-week xeloda protocol, which I prefer to the 5FU pump, especially when combined with Irinotecan, as it gave me an extra week between Irinotecan doses. I hope it goes well for you.
Dx June 2020, stage IV, w liver mets in both lobes. M, age 50. Right-sided colon tumor. CEA 120.
BRAF+ TMB 5% MSS TDL1-1%
July 2020 - Present: 55 cycles chemo (All the various 5-FU regimens)
December 2020 - February 2021 Y90 Radioembolization, Chemoembolization x2

pete305
Posts: 27
Joined: Mon Nov 23, 2015 8:02 am
Location: ohio

Re: Question on Irinotecan, 5FU, and Avastin experience

Postby pete305 » Tue Jun 20, 2023 9:06 am

anxious for input from others. avastin just added to my 5FU. had allergic reaction to oxaliplatin and irinotecan.
male, initial dx T3 N1c M0 - Stage IIIb in 2015
sigmoid colon resection 2015
folfox 2015-2016, 8 treatmts then allergic reaction to oxaliplatin
folfiri 2017 due to liver mets, RFA
folfiri 2018 new liver mets,
5FU and Avastin 2023 abdominal wall mets
lung mets from prostate cancer 2023 - zytiga and lupronRFA

behconsult
Posts: 264
Joined: Fri Jul 04, 2014 4:53 pm

Re: Question on Irinotecan, 5FU, and Avastin experience

Postby behconsult » Thu Jun 22, 2023 8:15 am

pete305 wrote:anxious for input from others. avastin just added to my 5FU. had allergic reaction to oxaliplatin and irinotecan.


Pete, I have been on Avastin for years. Initially with Capecitabine (5FU in pill). I never noticed ANY side effects at all. More side effects from eating fast food compared to Avastin for me. All the best, Bob
Stage 4 Age 56 BrafV660E 5/14
spot on perit/ Right side tumor
Resctn 6/9/2014
Folfox strt 7/2014. 6 of 12 tx
Chemo induced DM2
Pet 4 mets to lung (1 cm, 6 mm) Xeloda/Avastin 9/16 to present.
Cryo-ablation to four spots- Collapsed lung/chest tube 2x
Possible local recurrence in a spot or two on PET. Stable CT

pete305
Posts: 27
Joined: Mon Nov 23, 2015 8:02 am
Location: ohio

Re: Question on Irinotecan, 5FU, and Avastin experience

Postby pete305 » Thu Jun 22, 2023 8:33 am

thanks, bob. that's encouraging.
male, initial dx T3 N1c M0 - Stage IIIb in 2015
sigmoid colon resection 2015
folfox 2015-2016, 8 treatmts then allergic reaction to oxaliplatin
folfiri 2017 due to liver mets, RFA
folfiri 2018 new liver mets,
5FU and Avastin 2023 abdominal wall mets
lung mets from prostate cancer 2023 - zytiga and lupronRFA


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