Gilbert’s Syndrome and cancer treatment

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Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Wed Feb 22, 2023 7:28 pm

Hi all, a bit of a cancer-adjacent issue, but thought I’d share my experience and also see if the group mind has any advice for me.

Throughout my 4+ years of treatment (including a lot of liver-directed therapy), my bilirubin levels have never really been an issue. However over the past 6 months or so my total bilirubin has shot up rapidly; sitting around 30-40 mg/dL (1.7 - 2.2 mmol/L in US units), and in the last month has doubled to 60 mg/dL (3.3 mmol/L). Normal upper limit is 20 mg/DL (around 1.2 mmol/L). The thing is - all other liver markers are perfect (no enzyme elevation), there is no concern around obstructive/drainage disorders on liver imaging, and I have no symptoms of hyperbilirubinemia. I don’t have a gallbladder, so presume no risk of gallstones. Because of this, 3 oncologists have separately now concluded that I probably have Gilbert’s Syndrome (and my GP/PCP agrees).

Although it’s a bit strange that it only started to show recently, apparently Gilbert’s symptoms can be brought on by periods of physical stress or injury - eg cancer treatment. It seems to be a fairly common genetic condition (5-10% of males), and generally mild and asymptomatic. The only relevancy raised so far for my cancer treatment is, (1) dosage of irinotecan would need to be adjusted down for my diminished clearance rate, and (2) I would likely need to get an exemption from upper t-bili limits on clinical trials due to Gilbert’s Syndrome (apparently that’s usually recognised by investigators). Otherwise provided my other liver enzymes are fine and I’m asymptomatic, my oncologist(s) are not concerned. It may well be that Gilbert’s is the least of my problems.

However… like everything I’m conscious there’s a lot I don’t know, so interested if folk have any other experiences with this, or recommendations on how to manage.

Thanks,
Rob
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

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beach sunrise
Posts: 1080
Joined: Thu Mar 05, 2020 7:14 pm

Re: Gilbert’s Syndrome and cancer treatment

Postby beach sunrise » Wed Feb 22, 2023 8:40 pm

Never heard of Gilberts Syndrome. I will have to ask my ND about that.
When my bilirubin started to rise it was because my common bile duct was inflammed inside and outside for some reason and RBC's were affected by it also. We got it straightened out with hepogennesis, bilberry and a gallbladder supplement.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Thu Feb 23, 2023 8:09 am

Thanks beach sunrise - any insights welcome! I’ve picked up RP’s earlier suggestion of taurine supplementation to help with bili clearance.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

User avatar
beach sunrise
Posts: 1080
Joined: Thu Mar 05, 2020 7:14 pm

Re: Gilbert’s Syndrome and cancer treatment

Postby beach sunrise » Thu Feb 23, 2023 4:48 pm

Good deal, thats great!
The compound supplement I took had taurine.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

rp1954
Posts: 1867
Joined: Mon Jun 13, 2011 1:13 am

Re: Gilbert’s Syndrome and cancer treatment

Postby rp1954 » Sat Feb 25, 2023 12:47 am

Rock_Robster wrote:Hi all, a bit of a cancer-adjacent issue, but thought I’d share my experience and also see if the group mind has any advice for me.

My advice is to show all your blood work to more interested, capable, specialized people.
The whole enchilada can take on additional meaning and detail - continued whole dataset (extended) analysis is what we had to do to get ahead and respond in real time. Normal clinical practices are inherently 1 to 9 months more retrospective in different aspects.

The thing is - all other liver markers are perfect (no enzyme elevation), there is no concern around obstructive/drainage disorders on liver imaging, and I have no symptoms of hyperbilirubinemia.

I'm not sure what you call perfect.
The thing I found in the literature is that a lot of panels, especially in combination in particular "eras", can take on whole new meanings with colorectal cancer with quite different lab ranges.
For some panels, that's ca 0.5 - 1 * upper limit of the normal lab range becomes an early warning (2nd edit)

Most oncologists weren't that specialized, weren't reading their own literature, and couldn't be bothered. If it was important, NCCN, their oncology society or the sales reps would tell them. I try to bite my tongue and not be too critical because we had several advantages they don't have.

Because of this, 3 oncologists have separately now concluded that I probably have Gilbert’s Syndrome (and my GP/PCP agrees).

[shrug]"You're a pallative patient between scans with no immediate distress or approved indications, and we'll see you next time/month."

Although it’s a bit strange that it only started to show recently, apparently Gilbert’s symptoms can be brought on by periods of physical stress or injury - eg cancer treatment. It seems to be a fairly common genetic condition (5-10% of males), and generally mild and asymptomatic. The only relevancy raised so far for my cancer treatment is, (1) dosage of irinotecan would need to be adjusted down for my diminished clearance rate, and (2) I would likely need to get an exemption from upper t-bili limits on clinical trials due to Gilbert’s Syndrome (apparently that’s usually recognised by investigators).

You may be limiting your options to the std/conventional box several ways.
Last edited by rp1954 on Sun Feb 26, 2023 3:07 am, edited 2 times in total.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Sat Feb 25, 2023 3:33 am

I agree RP it does seem like the conventional view is to dismiss this based on asymptomatic and palliative patient. I’ll definitely be looking into it more.

Just so I’m clear on the inference - your suggestion is this might not be Gilbert’s but potentially something more sinister? It’s a relatively easy blood test to confirm Gilbert’s, so perhaps that’s worthwhile having done.

When you say this may have limited my options to conventional treatment in ‘several ways’, are you referring to beyond qualifying for clinical trials?

Thanks,
Rob
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

rp1954
Posts: 1867
Joined: Mon Jun 13, 2011 1:13 am

Re: Gilbert’s Syndrome and cancer treatment

Postby rp1954 » Sat Feb 25, 2023 9:47 am

Rock_Robster wrote:Just so I’m clear on the inference - your suggestion is this might not be Gilbert’s but potentially something more sinister? It’s a relatively easy blood test to confirm Gilbert’s, so perhaps that’s worthwhile having done.

My view is that they aren't sure, or are not discussing possibilities because they have no indicated action items "today".
This can lock you into std trajectories when it is still technically possible to maneuver, beyond std.
e.g. if it's chemo damage or if it's early signs of met activity, they won't act very often or very much from their limited menu, so to them there's nothing to discuss.
Vs with my wife we could fine tune or make changes each blood test to try to improve measurements, improve actual results and anticancer activity.
In your shoes, I'd probably do whatever Gilbert's Syndrome test(s) and sharpen up on the expanded blood testing, maybe add a ctDNA.

When you say this may have limited my options to conventional treatment in ‘several ways’, are you referring to beyond qualifying for clinical trials?

First, your comments show you're not breaking out of the box from conventional data analysis of the data you do have, and hence impairs your ability to improve your own follow up. I know it's not easy and it's not likely to be one stop shopping. Beyond a certain point, digging the papers out is a time intensive option. Asking for help is faster.
Second the more detail you present on the forum can better attract others' experiences, data comparisons, and opportunities otherwise likely missed.
Third, being better informed can help you actively find and qualify for trials, or running your own.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

roadrunner
Posts: 477
Joined: Sun Jan 12, 2020 8:46 pm

Re: Gilbert’s Syndrome and cancer treatment

Postby roadrunner » Sat Feb 25, 2023 12:11 pm

Rob: IMO your exchange with rp1954 is an interesting—and perhaps strategically material—discussion. My concern is something you said above, namely, that “it’s a bit strange that [the possible Gilbert’s Syndrome] only started to show recently, apparently Gilbert’s symptoms can be brought on by periods of physical stress or injury—e.g., cancer treatment.”

You’ve had a very substantial amount of treatment, including surgeries and serious non-surgical therapeutic interventions, over the last few years. And I assume that you’ve had innumerable bilirubin tests/hepatic enzyme panels. Yet this seems (from your account) to be novel. So the “strange” aspect appears two-fold: Not only did the (potential) Gilbert’s symptoms fail to appear before generally, but they don’t seem to have been a concomitant phenomenon to your many cancer treatment stresses. To me, that is potentially significant. I would *at least* discuss that specific issue with the oncologists providing the diagnosis. Also, your point about the “simple” test is a good one: wouldn’t it make sense to find out?

My sense is that while you are realistic about the challenges you face, you are doing everything reasonably productive to gain time, and perhaps even eventual victory over your disease. While—with respect—I don’t share all of rp1954’s negative perspectives on SOC/conventional oncologists, I agree with his view that they (IMO by the nature of their job, including the volume of diverse patients that they see) can bring in unacknowledged/undisclosed perspectives to consultations that are divergent from ours as patients—particularly from highly informed and engaged patients like you. Here, I’d say this—going solely on your personality and perspectives evinced on this forum: If there’s a simple test for this syndrome, wouldn’t it be better to know? I believe you might wish to explore other explanations, and perhaps therapeutic options, if it is not present.
7/19: RC: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/19-10/19 4 rds.FOLFOX neoadjuvant, 3 w/Oxiplatin (reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
6/20/22 TAE rectal polyp benign)
NED from 3/22 - 3/23
4 cycles FOLFIRI
LUL VATS lobectomy for radio resistant met 7/7/23

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Sat Feb 25, 2023 11:18 pm

Thanks for the perspective all, indeed getting the test now seems a no-brainer, and I’ll organise it.

Also need to keep in mind that even if I am Gilbert+, that doesn’t automatically mean that’s the reason for high bilirubin.

ctDNA is a good suggestion now too, given my other data is a bit patchy.

Cheers,
Rob
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

rp1954
Posts: 1867
Joined: Mon Jun 13, 2011 1:13 am

Re: Gilbert’s Syndrome and cancer treatment

Postby rp1954 » Tue Feb 28, 2023 8:45 pm

roadrunner wrote:My sense is that while you are realistic about the challenges you face, you are doing everything reasonably productive to gain time, and perhaps even eventual victory over your disease

The major aspect of gaining victory over palliative treatment is to have biologically plausible plans to bridge the gaps in std medicine to convert to a curable, -ed patient and then treat it like a major project where you have to complete all the steps of the project. Preferably each step has good historical examples . Often important answers do remain obscure for various (common) reasons.

With my wife, improved measurement and interpretation were foundational to any path forward, especially multiple steps beyond the std of care box. Once we had identified technical components and project steps, the medical obstructions were really psychological, social, economic in nature rather than true technical show stoppers.

Basically, once something is available somewhere in the world or even doable, it shifts to more to psychological, social and economic dimensions, much of it in the medical systems rather than patients.
Many of the unused or under utilized techs are more favorably done at home.

Time and timing also become bigger considerations with more advanced metastatic disease. My view of incurable and too late for cure is structurally different in a situation where delay can be a very deadly form of denial.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper chemo to almost nothing mid 2018, IV C-->2021. Now supplements

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Wed Apr 19, 2023 9:42 am

Just updating for completeness… got the genetic testing back and I do indeed have Gilbert Syndrome! Honestly that’s quite a relief at this stage given the prolonged isolated high bilirubin
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

User avatar
beach sunrise
Posts: 1080
Joined: Thu Mar 05, 2020 7:14 pm

Re: Gilbert’s Syndrome and cancer treatment

Postby beach sunrise » Thu Apr 20, 2023 12:53 pm

Good you now have a clear dx. I haven't looked it up yet myself but do you know how to tackle it yet?
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Fri Apr 21, 2023 12:56 am

beach sunrise wrote:Good you now have a clear dx. I haven't looked it up yet myself but do you know how to tackle it yet?

No worries at all beach sunrise.

Management is pretty hands off - the main things seem to be staying very well hydrated, and avoiding paracetamol/acetaminophen. Irinotecan needs to be dose-adjusted too, which my onc is across. There is some suggestion that fasting with Gilbert’s is a bad idea too, which is disappointing as I wanted to include that in my next treatment - might have to trial and error that one a bit.

I will still have to argue with trial leads about qualifying with high bilirubin, but having evidence for Gilbert’s is helpful in getting an exemption for that (as it isn’t actually liver injury).

Hope all is going well your end!
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

rnb828
Posts: 6
Joined: Sun Oct 16, 2022 11:52 am

Re: Gilbert’s Syndrome and cancer treatment

Postby rnb828 » Fri May 19, 2023 8:44 am

Hi Rob,

We also recently discovered my husband has Gilbert’s Syndrome during the course of his treatments. After about 6 rounds of FOLFOX, his bilirubin was slightly elevated (ranging from 1.2-1.7), but his other liver enzymes were normal, so our oncologist suspected Gilbert’s, and sure enough, a blood test confirmed it.

My biggest concern was if this would affect the potential use of irinotecan if we were to need it down the line. His response was similar to your oncologist, that we would just need to adjust the dose & monitor accordingly.

We aren’t doing anything special at the moment to manage it, and his bilirubin has dropped back to 0.7 (he has been off FOLFOX since Feb, and had a partial liver resection in April. He just started Xeloda last week).

In my very limited research, I’ve seen some suggestions that those with Gilbert’s should limit their aspirin use, which stuck out to me, as we were planning to have my husband start taking a daily low-dose aspirin. So that’s something I need to discuss with our oncologist & dig into a bit more.

I also saw the suggestion that fasting should be avoided, so I would be curious about your experience if you try any type of adjusted protocol.

Thanks for bringing this topic up, and if we come across anything interesting or useful in our experience, I will definitely add.
Wife of Dx 8/2022 (42 yr old)
Stage IV- Sigmoid Colon, Liver/LN Mets
MSS/KRAS G12A
Baseline CEA-65; Began FOLFOX w/Avastin 9/22
4/23- Liver & Colon Resection (T4bN0M1a)- 0/23 LN
5/23- Began Xeloda; CEA 5
7/23- CEA 3

Rock_Robster
Posts: 1038
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Gilbert’s Syndrome and cancer treatment

Postby Rock_Robster » Fri May 19, 2023 7:21 pm

Welcome to Club Gilbert!

Yes I believe the onc reduced the irinotecan in my XELIRI to around 150 mg/m2, which was fine.

I notice my bilirubin moves around quite a lot, and I did have a faint amount of jaundice in my eyes after chemo for a day or two. I understand this isn’t dangerous with Gilbert’s, but can be unpleasant (fatigue, digestive issues, brain fog etc.). I did fast for a few days around this last chemo - again my understanding is that fasting can cause additional elevation of bilirubin, so I guess as long as you’re monitoring it and you’re not having unpleasant symptoms it could be ok. Staying hydrated is hugely important with Gilbert’s - I ended up back in hospital on day 4 after irinotecan to get a bag of fluids because I wasn’t consuming enough water myself. After that I started drinking around 500 ml/hr of electrolyte drink for a couple of days and was in much better shape. Lesson learned for next time.

I hadn’t heard about aspirin, but was aware of paracetamol/acetaminophen - I guess it just depends which liver enzyme is used to process it. Overall a good question to ask your onc perhaps.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial


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