I’m avoiding added folate / folic acid and doing the topical treatments for the HFS (urea cream, etc) but wondering what peoples’ views on systemic treatments for side effects are that don’t interfere with efficacy? I’ve seen decent data for celebrex (celecoxib) which seems to be synergistic with Xeloda anyway so will restart that, but also hearing melatonin? I was taking 30-40mg nightly anyway but the onc pharmacist suggested I stop due to antioxidant effects on the Xeloda. Any thoughts welcome!
"Using dexamethasone together with celecoxib may increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation. Gastrointestinal perforation is a potentially fatal condition and medical emergency where a hole forms all the way through the stomach or intestine. You should take these medications with food to lessen the risk. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Your doctor may also be able to recommend medications to help protect the stomach and intestine if you are at high risk for developing serious gastrointestinal complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor."
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