Signet Ring Cell Carcinoma + Malignant Ascites, T4N3Mx - Looking for feedback
Posted: Sat Oct 22, 2022 4:57 pm
Hello everyone,
my father was diagnosed with Signet Ring Cell Carcinoma of the colon (pathology of the tissue T4N3Mx) and malignant asites. The tumor (8cm) was located in cecum near the ileocecal valave. 6 of 16 LN came back positive, including the distant superior mesenteric LN. He had an extended right hemicolectomy. The surgeon said that all macroscopic cancer tissue was removed. Unfortunately to make it worse, there was also ascites in pelvis which was positive for malignant cells, which I guess makes it Stage IV.
Short chronology of the recent events:
Apr-2022: Routine CT scan, all fine
Jun-2022: Bowl camps, fullness, constipation, IBS like symptoms. Ultrasound: all fine. Wight loss (7 kg)
Jul-2022: PET Scan all clear, minimal ascites in pelvis, CEA 1.8
Aug-2022: Using anti bowl spasms medications.
Sep-2022: CT scan 8cm tumor in cecum, minimal ascites. CEA 1.7. No suspicion on malignant ascites due to prior history of ascites (liverchirrosis)
Sep-2022: Surgery: Right extended hemicolectomy, many enlarged lymph nodes observed, ileum obstructed, no peri mets visible. No liver mets visible. Very slow recovery after surgery.
Oct-2022: Pathology: T4N3Mx, malignant ascites, colon origin (CK7-/CK20+/CDX2+/-).
Oct-2022: KRAS test on the way, in order to add Cetuximab.
We have met with the Oncologist, based on statistics the prognosis is quite shocking, however she is a bit optimist that FOLOFOX+Cetuximab could be a bit effective (hopefully). We'll do other molecular test if needed. Avastin (bevacizumab) is also being considered but not recommended after surgery as it can cause anastomosis leak.
I've read a lot about Signet Ring Cell Carcinoma, its poor prognosis, extremely aggressive with poor response to chemo. I'm feeling a bit comfort and lucky that I found this forum, needless to say I'm in the same boat as may of you. I was shocked and speechless when I red the pathology reports.
Malignant ascites have complicated the prognosis to quite worse. I fear that malignant ascites will lead to the inevitable peritonimum mets, progressing even during chemo.
I would highly appreciate if you could share some similar experiences or your stories about the treatment and the outcomes.
Many thanks,
R.
my father was diagnosed with Signet Ring Cell Carcinoma of the colon (pathology of the tissue T4N3Mx) and malignant asites. The tumor (8cm) was located in cecum near the ileocecal valave. 6 of 16 LN came back positive, including the distant superior mesenteric LN. He had an extended right hemicolectomy. The surgeon said that all macroscopic cancer tissue was removed. Unfortunately to make it worse, there was also ascites in pelvis which was positive for malignant cells, which I guess makes it Stage IV.
Short chronology of the recent events:
Apr-2022: Routine CT scan, all fine
Jun-2022: Bowl camps, fullness, constipation, IBS like symptoms. Ultrasound: all fine. Wight loss (7 kg)
Jul-2022: PET Scan all clear, minimal ascites in pelvis, CEA 1.8
Aug-2022: Using anti bowl spasms medications.
Sep-2022: CT scan 8cm tumor in cecum, minimal ascites. CEA 1.7. No suspicion on malignant ascites due to prior history of ascites (liverchirrosis)
Sep-2022: Surgery: Right extended hemicolectomy, many enlarged lymph nodes observed, ileum obstructed, no peri mets visible. No liver mets visible. Very slow recovery after surgery.
Oct-2022: Pathology: T4N3Mx, malignant ascites, colon origin (CK7-/CK20+/CDX2+/-).
Oct-2022: KRAS test on the way, in order to add Cetuximab.
We have met with the Oncologist, based on statistics the prognosis is quite shocking, however she is a bit optimist that FOLOFOX+Cetuximab could be a bit effective (hopefully). We'll do other molecular test if needed. Avastin (bevacizumab) is also being considered but not recommended after surgery as it can cause anastomosis leak.
I've read a lot about Signet Ring Cell Carcinoma, its poor prognosis, extremely aggressive with poor response to chemo. I'm feeling a bit comfort and lucky that I found this forum, needless to say I'm in the same boat as may of you. I was shocked and speechless when I red the pathology reports.
Malignant ascites have complicated the prognosis to quite worse. I fear that malignant ascites will lead to the inevitable peritonimum mets, progressing even during chemo.
I would highly appreciate if you could share some similar experiences or your stories about the treatment and the outcomes.
Many thanks,
R.