He started neoadjuvant FOLFOX on 5/13/2021. We switched to FOLFIRINOX from cycle 2 onwards and completed a total of 8 cycles of neoadjuvant chemotherapy on 9/2/2021.
rp1954 wrote:What you need to do is achieve some combination of chemical components that slow or kill SRCC cells in various locations, the more locations the better, AND try to improve/preserve immune function and quality of life.
You've got several possible directions
1. Collect several conventional recommendations for treatment, you may see variation and get added bits of information each time.
2. Look for complementary treatments to regular treatments
3. Look for alternative treatments with varying kinds of medical or biological basis
4. Look for conventional trials
To get beyond, Step 1, you need to try to achieve the extra steps each day, and not stop for long on insurance approvals. Our first year, we just paid cash on smaller stuff without the delays fighting or begging - I realized both of us might suffer serious damage fooling with insurance bs.
We found a lot of low hanging answers this way that were useful, some critically so, but not readily available in Std.
MadMed wrote:Hi R.
I'm sorry about your father's situation. There's no way of hiding it, it's bad. I am one of the lucky few SRCC. We make as rp said 1% of CRC, so there's very, very little data on our specific subtype.
RP gave you some good advice, I can add a couple. Get an NCI accredited center. Get second opinions on everything. Move fast, don't delay, this subtype works fast.
If your Dad can handle FOLFIRINOX, get it. It is a rough regiment but may give your Dad a good shot.
This seems like a new cancer rather than the original gastric one ? Is that true ? Was the original cancer SRCC ?
I wish you the best, this thing is hateful!
"...Oct-2022: KRAS test on the way, in order to add Cetuximab...
Peregrine wrote:Ron --
As everybody has mentioned so far, time is of the essence right now. It's important to act quickly and do something effective now before things get really out of control.
But you need to have good advice to begin with. How are you doing on finding good doctors and good cancer hospitals near where you are? When will you be able to get some second opinions, and when will you be able to test for even more biomarkers to get a better picture of your father's specific SRCC profile?
2. What is your father's body mass index (BMI)?
3. What kinds of medications is your father on right now? And for what purpose?
4. What is your father's current state of mind? What does he think of all of the prognoses and about the different treatment approaches that might be taken right now, even the ones that might be somewhat toxic and unpleasant? It should be noted that stress, anxiety, depression, etc., have a bad effect on the immune system. Your father needs to have a good, functional immume system to help fight off this new cancer.
5. Is your mother available to give your father some emotional support?
9. P.P.S - Have you discussed the possibility that your father's type of SRCC might be hereditary? Have you yourself been tested for the CDH1 gene mutation? https://www.mskcc.org/news/6-things-know-about-cdh1-gene-mutation-and-stomach
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