Rock_Robster wrote:Niacinamide - 2000mg (increasing - meant to be 3000mg)
that is really going high - maybe, maybe not on tolerance. Both niacin and niacinamide have anti-inflammatory properties but are different in benefits, side effects, and pharmacology. They are incompatible with statins, amongst statins' bad habits. Although I bought bulk nacinamide, we've tended to use niacin (nicotinic acid) but responses can be very individual. Pure, instant release niacin is strongly preferred by Abram Hoffer MD over time release forms of niacin including safety.
PSK - 3000mg
I think you mean Coriolus concentrates that have 30- 45% PSK in them, maybe higher but I'm cautious about PSP substitution quoting higher %.
Apparently the Japanese PSK papers may have quoted actual PSK content in many cases. e.g. 3000 x 42% = 1260 mg
In any case, my wife actually had near linear WBC response up to 6000 mg of SuperStrength Coriolus at 42% concentrate (actual batch assay).
Vitamin D - 5000-10000mg
When my wife still had unbiopsied liver lesions (mCRC, primary liver cancer, cysts?) they broke up and mostly dissolved when we went much higher on D3 dose (plus everything else), with the paid advice of Dr. JJ Prendergast, an endocrinologist who had described the dissolution process in various organs at 50,000+iu. There are medical high dose vitamin D3 protocols (ingredients. monitoring) to do this, to avoid mostly calcium toxicity. I speculatively view extreme dose D3 ( 50k-200k) as its best met effect for a limited time, so I classify CRC patients' therapeutic hydroxy vitamin D blood levels as 60-100 ng/ml vs 100-150 ng/ml vs the unstable Great Beyond high dose, in extremis.
Curcumin - 3200mg equiv. of theracurmin.
Some patients with other kinds of cancer go as high as 12-13 grams for specific performance. We used 1-2 pills per day, 650 - 2000 mg but I definitely would willing to go higher, as needed. Often 1 pill is the most important but higher maybe needed for specific performance.
EGCG/Resveratrol - 400-800mg
Bought bulk EGCG cheap but stayed at 400 mg after I found out about its burdens above 750 mg.
Resveratrol, pricey, we mostly used at 300-500 mg but willing to try 750 - 1000 mg. I think resveratrol is specifically important.
Celebrex - 200mg [celecoxib]
is there a problem at 300 - 400 mg of celecoxib? my wife side effects and benefit were very dose dependent while on chemo
Loratadine - 10mg no experience here
Aspirin - 300mg - we mostly used 81-100 mg several years for possible mutations
Beta Glucan - 2000 mg - what brand/quality (% of assayed active isomers but unclear ocurrent brand lab abilities)
Silymarin - 600mg
Quercetin - 1000-3200mg I've been quoted up to 4000 mg in use but maybe more in upper limit.
Andrographis - 2000-4000mg aware of but no experience
Alpha-Lipoic Acid 150-600mg
R- purified form, or R, S- racemic mixture?
900 mg per day R- form is a hard limit
we used R,S-ALA a lot the first year when we had a vitamin milkshake that she tired of
Doc wants me to take phenylbutyrate too which I’m working on but it’s pretty hard to get here.
I have it but we never used really used it, bulky too many items on my wife oral intake - low pill burden, which actually a small part of why she did so much IV vitamin C which is preferable on KRAS forms of CRC, and on 5FU, especially Xeloda for hand foot syndrome.
It was easy to get mail order in US ca 2010. Is TGA (Oz's FDA) too strict for personal mail or walk in with?
DCA - 1000mg
2DG - 1000mg (either this or DCA)....
The 2DG had to come from a lab in the UK. According to his most recent plan I also need to add D-Mannose and hydroxycitrate.
I'm not a DCA fan because of toxicity/body burdens and unsure of performance.
I'm more neutral on 2DG but unsure of performance, no personal experience.
Two friends could not observe specific 2DG performance benefits.
We went the IV (mega)vitamin C route, with megavitamin K2 and B12 (+chemo).
LDN - 3mg
Melatonin - 30-40mg ...
He also wants me to ramp up to 180mg melatonin but I must admit I’m less confident about this one.
I could not observe anything specific with LDN in 1-2 months and it was a hassle for us.
Wife uses melatonin now but refused 10-12 years ago. For me, 21 - 200 mg melatonin is undescribed territory that any repeated discussions or papers would be appreciated.