Stereotactic Body Radiation Therapy and Immunotherapy

[stu]

Looking forward to seeing how this works for you .
All the very best . Sounds extremely positive .
Stu

[Markdale]

I’m hoping it works

[beach sunrise]

Hey pccr, Thanks for the update. I hope and pray for good results coming your way!
Keep pushing on and its really good plan B is in place for just in case.
I am cheering for you.

[roadrunner]

I also wish you the best. The way I understand it, success on the immunotherapy front would be icing on the cake, no? And if it isn’t there, you just proceed to the promising experimental therapy you sought through enrolling in this trial. That seems like a reasonably good & hopeful place to be. In any event: Good luck, we are all pulling for you!

[MadMed]

This seems weird to me, spread to adrenals from CRC is rare unless in stage 4 spread everywhere. Seems to me more of a side effect of immunotherapy.
I hope that's the case pccr. The chest scan results are the key now.

[roadrunner]

I think there’s some reason for concern and vigilance here, but also a silver lining, perhaps? First, this would need to be confirmed as a met. The interval growth/appearance is the concern, of course, and though I don’t know the interval, I suspect the growth rate is concerning. Whether immunotherapy or the alternative therapies you pursue could be involved is beyond my knowledge.

The more positive piece here, I think, is that this may well say little about the lungs or other areas in the body. Metastases in the adrenal glands are famously resistant to the effects of immunotherapy. Much research has been done to determine the reason, but I haven’t seen a definitive answer. In any case, that suggests that the therapy might be having positive effects elsewhere, or that your immune system was controlling disease better elsewhere, or both. The lung scans, therefore, may not be bad even if this is a met. The same goes for the overall picture, I believe.

It does raise potential questions for next steps. I have no clue as to whether TIL therapy could affect an adrenal met, and I doubt the folks leading the study will either. Adrenal mets are usually treated via surgery, so the timing of that and how it might interact with TIL therapy (if necessary) and the trial protocol may become important questions. Again, most of the above presumes that this finding does represent disease, which I hope is not the case.

[MadMed]

Progression in the lung mets ? Sorry pccr, gut punch.