Phase 1 trial.

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Markdale
Posts: 109
Joined: Wed Dec 02, 2020 4:45 pm

Re: Phase 1 trial.

Postby Markdale » Tue Oct 17, 2023 5:40 am

Hi all, I’m continuing on the trial for the moment with tislelizumab added. Ive developed some severe shoulder pain and moderate hip pain which I assume is because of the pd1 blocker. I’ve had slight pain in these areas before but now it’s at point where im complaining about it, I know immunotherapy drugs can cause these problems but the pain is a lot. I might use this to get a script for celecoxib. After a year my nodules have remained stable.
09/20:Diagnosed colonoscopy
10/20: LAR tumour t3n2m1 4/24 lymph nodes.
11/20: pet scan confirmed Mets
11/20: folfoxiri - 10/6/21. 12 rounds in total
1/1/21 thoracotomy 1 met removed
2/2022 sabr to 2 lung nodule
09/22 PET scan progression of sabr’d nodules
10/22 phase 1 trial bispecific antibody
9/23 added pd1 blocker
12/23 bilateral VATS all visible (7) lesions removed
3/24 radiation to acromion bone met + chest lymph nodex2

User avatar
beach sunrise
Posts: 1062
Joined: Thu Mar 05, 2020 7:14 pm

Re: Phase 1 trial.

Postby beach sunrise » Tue Oct 17, 2023 8:00 am

Hey, this is a good report..STABLE!!! YES
The bone pain sucks. It can really knock you down. Maybe the celebrex will help.
Let us know how it goes.
8/19 RC CEA 82.6 T3N0M0
5FU/rad 6 wk
IVC 75g 1 1/2 wks before surgery. Continue 2x a week
Surg 1/20 -margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24 post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
CEA
7/20 11.1 8.8
8/20 7.8
9/20 8.8, 9, 8.6
10/20 8.1
11/20 8s
12/20 8s-9s
ADAPT++++ chrono
CEA
10/23/22 26.x
12/23/22 22.x
2023
1/5 17.1
1/20 15.9
3/30 14.9
6/12 13.3
8/1 2.1
Nodule RML SUV 1.3 5mm
Rolles 3 of 4 lung nodules cancer
KRAS
Chem-sens test failed Not enough ca cells to test

Bpaint
Posts: 68
Joined: Sun Oct 11, 2020 8:54 pm

Re: Phase 1 trial.

Postby Bpaint » Tue Oct 17, 2023 10:50 am

One year stable on a trial is great, congrats!
husband (age 41 at dx):
8/20 CRC Stage 4. Mets to lungs, liver, distant lymph nodes
MSS, KRAS wild
CEA 713 at dx
Folfox (12 rounds)
Liver, colon and node resection 4/21
New lung mets, Vectibix monotherapy started 6/21
Stop Vectibix lungs stable about 6 months; all other areas stable
Start Folfiri + avastin 1/22
Stop Folfiri (lungs stable 6 mos); start Vectibix 7/22
Stop Vectibix 12/22 (lungs stable 5 mos this time)
SBRT on lung Mets scheduled for 1/22, will restart Folfiri

Markdale
Posts: 109
Joined: Wed Dec 02, 2020 4:45 pm

Re: Phase 1 trial.

Postby Markdale » Tue Dec 05, 2023 3:34 pm

Over the last few scans there have been small but steady increases in the size of 2 of the nodules, so we decided to finish the trial. They believed the trial slowed the progression for a while.
The oncologist believes surgery is still an option, I’ll have to go have a chat with the thoracic surgeon.
09/20:Diagnosed colonoscopy
10/20: LAR tumour t3n2m1 4/24 lymph nodes.
11/20: pet scan confirmed Mets
11/20: folfoxiri - 10/6/21. 12 rounds in total
1/1/21 thoracotomy 1 met removed
2/2022 sabr to 2 lung nodule
09/22 PET scan progression of sabr’d nodules
10/22 phase 1 trial bispecific antibody
9/23 added pd1 blocker
12/23 bilateral VATS all visible (7) lesions removed
3/24 radiation to acromion bone met + chest lymph nodex2


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