Without being up to date on various options with hi-tech VATS flavors now, I would favor surgical biopsy - whole removal.
Both for the extra cancer and cellular information, some certainties, with potentially curative surgery.
At least locally, since beach sunrise uses a potent daily treatment beyond ADAPT+++, that has potential advantages against new seeds circulating.
Since my wife had a large conglomerated LN mass to deal with, over 14x above minimum for our sample half, the post doc lab owner commented that it was pretty beat up chemowise (daily UFT+++) but enough survivor cells to do kill tests.
10-12 years ago liver/lung ablations here were really pallitive care, good for 1-4 tries and then usually SOL, lung ablation being more dicey.
I don't know their current batting averages.
What little information I saw from others showed that ablation drove the inflammation and cancer markers wild and frequently recurred.
Many experienced hands here recognize the problem to find, and get, the true best techniques. Like Rolle's laser lung surgery in Germany 12 yrs ago, over VATS in US for numerous mets that would be inoperable in the US. The other problem is that surgeons often dismiss conditions as inoperable because they don't recognize advanced treatment efforts beyond their training e.g. we took pains to stop new LN mets via daily tx with extra aggressive chemistry and so we worried less about other met sites frustrating the benefit of a locally curative surgery. So when our 2nd surgery surgeon panicked over the metastatic nature of the conglomerated LN removed, we were less concerned because of the demonstrated daily chemo, hell or high water.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C