MadMed wrote:I think you are as well informed as possible. With all the caveats you listed, it's a good sign. One thing I wonder is about the initial signatera draw. They need to have a biopsy of some kind (tissue or liquid). Did you have that done ?
Edit: I saw your other post, so you had the first draw with the tumor markers.
MadMed, thank you for replying.
Oh yes, The tissue was put in paraffin blocks after surgery in july 2020 and it was kept in my hospital. Then in june 2022 they took part of this tissue and sent it to the Natera lab. Presumably they use this to identify 16 mutations found in the tumor.
In paralel the drew a tube of blood to see if they could find traces of the mutated DNA from my tumor tissue in the sampled blood. This is what I referred to as "initial draw".
Then I think every few months they will take blood and check for the mutations again. They call this "longitudinal or serial testing"... which repeated over time is meant to provide greater sensibility.
Natera claims 97% negative prognostic value after repeated testing for two years. Other studies say it is not more sensitive than Imaging and CEA together. (But since CEA is not a good marker for me I guess Signatera will be better for me)
Anyhow, thanks again and good luck.