The Colon Club

Pfccr: I’m going to echo Claudine’s good wishes. As you know, this is a very promising therapy, and I think there’s a good chance you will see significant benefits from it. I hope you get the kind of response you did to your primary with TNT, but even if it doesn’t go quite that far, there seems to be a good chance it’ll carry you forward to other positive steps. Good luck!

As I expect you’ve seen, there are a number of small published studies that have shown quite substantial gains in PFS and OS vs. controls in CRC, so it’s clear the therapy is active if well-designed. And as I think you also know, the approach in general is “hot” in the solid tumor area—lots of people are trying to fine tune it so as to get results similar to those in hematological malignancies and melanoma. I don’t know what specific therapeutic angle or dosage approach your trial employs, but past successes in CRC do suggest that further improvements are on the horizon, and may already be here. That’s probably why your doctors are optimistic. I hope they’re right!

Even better. Then if there advances to be had, you’re in the right place to get them.

I understand how that sounds, but I assume that’s their low-end “success” threshold, though they hope for more, no?

How many lesions do you have, PRAYINGFORCCR? Are they all located in the lungs or are you planning to also execute ablation in the (likely) adrenal gland?

Hello, PRAYINGFORCCR

I remember in the past to read several comments about a procedure with laser to clean up lung nodules. Several discussions happened around 2018-2019, when I discovered I had cancer. This is why I remember this topic. I can see comments from non-cancer forums from around 2009 about this procedures, so, by now it is more than tested and approved. The procedure can clean up A LOT of nodules (up to 100 at a time) with a very good outcome. I am not a doctor, but maybe it would worth doing some research.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6753410/

I remember in the past there was only one doctor expert on this procedure, named Alex Rolle, but I know he trained several others around the world.
https://www.ctsnet.org/home/arolle

Below is a link for some discussions on this topic. On this forum or on the "Cancer Survivor Network" there is more about this procedure.

https://csn.cancer.org/discussion/comme ... nt_1611383 (one generic topic about colon cancer metastized to lungs and thi treatment)
https://csn.cancer.org/discussion/31354 ... e-to-lungs (another thread where people also mentions the treatment)

Maybe the advantage for you would be to possibly remove all lung mets at once and still keep a lot of healthy lung parenchyma. This could reduce the impact of the surgery on your quality of life if compared to other treatments that might remove a lot of lung tissue.

Again, I think some more research on the topic is needed, but maybe this is one more possible alternative for you. Let me know if I can help somehow.

Cheers

Hey, hello, PryingforCCR

I am sorry. I added some info about the laser treatment of lung mets, but looking at another thread on this forum I can see you are completely aware of the doctor, procedure, etc... I believe the answer above did not added much to your current knowledge and options.

theDruid

I really hope the TIL therapy helps you. It has great potential, as you know.

I’m sorry to hear that. It’s surprising to me and obviously disappointing. I would have thought they’d be shooting for more.

If it gives you more time to go thru the acceptance in Mexico or Germany it is worth it.

Don’t think I’d seen this one, but others that were similar. Certainly seems promising. That 2010 study had great results. I wonder what’s up with the lowered expectations here. Maybe mutational level was a factor? Perhaps you have already inquired into that stuff; certainly Rosenberg would know where the state of the art is.

In the article you linked above, this one:

“In a clinical trial (NCT01373047) of 16 patients with CRC, infusion of expanded sentinel lymph node (SLN)-derived CD4+ T helper 1 (Th1) cells induced an antitumor response, and complete tumor regression occurred in four of nine stage IV patients with distant metastases (131).”

“131. Karlsson M, Marits P, Dahl K, Dagöö T, Enerbäck S, Thörn M, et al. Pilot study of sentinel-Node-Based adoptive immunotherapy in advanced colorectal cancer. Ann Surg Oncol (2010) 17(7):1747–57. doi: 10.1245/s10434-010-0920-8”

My onc works with DR.Williams with certain patients.
I sent my scans to him last year. Didn't hear anything back so inquired about why not. Found out he moved his practice and sent scans to old place and he never received them. No idea what happened to the scans.
I might have to try him again also.

That sounds rather positive? Wishing you much luck with your upcoming treatment!