Beginning TIL Therapy at NIH Next Week

[prayingforccr]

Thank you, everybody.

I wasnt expecting good news headed up to md, but when I saw my cea (1.4) and confirmed it was the correct base/factor, I got a little anxious.

I am beginning the 20 day artemisinin protocol tonight, will be alternating fenben and niclosamide dissolved in dmso each day, daily liposomal curcumin, and will take ivermectin dissolved in vodka every other day until my next scans.

I’m going to kill these lesions.

[beach sunrise]

Impressive results so far!

[prayingforccr]

Impressive results so far!

Wasn’t going to get too down if scans/bloods weren’t good.

Not going to get too high with this latest news.

But, it’s the first time in over a year and a half that I’m not living under a 24/7 damocles sword of imminent, inevitable self demise.

I have hope.

The cea of 1.4 is nuts.

[prayingforccr]

Hi Dr G

Just curious if Dr Rosenberg has seen my early results, and if so, in any comments/thoughts relayed to you and the team?

REPLY

Yep! The whole team including Dr. Rosenberg is very excited by the response we are seeing. He emphasized that we keep a close eye on your follow up. It does happen that we see a good response on the first set of scans but then see growth layer— so it is really the durability of the response that we get most excited about. It will be very telling to see what your next set of scans look like.

Hope that helps some.

Stay well.

So………….wasn’t going to get too down if results were poor/stable. Haven’t gotten too crazy excited with latest positive tests.

But I’ll take good results anytime I can get them. They’ve been rare the past two years.

Last infusion of keytruda this week, then chill until scans first week of march.

After a considerable amount of thought, Ive held off any supplements/protocols, and will continue to do so through next scans, as I want a very clear picture of how the TILs alone are working (or not).

I will definitely be augmenting them regardless of results in March.

[beach sunrise]

The good results so far is a WIN!!!
You have been thru hell so great attitude you have now.

[roadrunner]

I agree with Beach and the others—this is definitely a big win!

In light of your trial team’s excitement, do you know what their specific innovation(s)/differentiation with this trial’s TIL approach is? Also, did they drop any hints as to whether you’re an outlier in their trial, or are they seeing promising results across the board? (I understand they may keep that close.)

[prayingforccr]

I agree with Beach and the others—this is definitely a big win!

In light of your trial team’s excitement, do you know what their specific innovation(s)/differentiation with this trial’s TIL approach is? Also, did they drop any hints as to whether you’re an outlier in their trial, or are they seeing promising results across the board? (I understand they may keep that close.)

Well…….my Resident’s quote was “We were due for a win around here”.

From my understanding, the approach has much greater success with blood cancers and melanoma than it has had in epithelial cancers.

I put the chances of home run success in my case at around 5% prior to treatment based on my research and coded discussions with a few of the doctors.

I’m nowhere near spiking the football, but I’ll take good news where I can get some.

The approach was very straightforward; lesions resected by vats, extract t cells from lesions, test in vitro for response, multiply/expand tils in lab, reduce immune system to near 0, one infusion of keytruda, infuse tils via port/line, administration of as much interleukin 2 as blood tests advise (3 in my case), neupogen injections, recovery until bloods reach levels that allow you to go home, keytruda infusions every three weeks for a total of four, scans at 6 and 12 weeks.

Happy to answer any questions/fill in anything I missed.

[prayingforccr]

Final keytruda infusion in the books.

CEA ticked down to 1.3 (from 14, 1.7, 1.4)

Super Bowl of scans in three weeks.

[beach sunrise]

Hopefully you are at the finish line with this.

[Jacques]

... scans first week of March....

This is the first week of March ...

Any news?

[prayingforccr]

... scans first week of March....

This is the first week of March ...

Any news?

Headed to maryland today.

Scans/results/meetings tomorrow.

[IM64]

Good luck! Everything should be fine.

[prayingforccr]

Sending out some good news to everybody…….todays scans show the lesions in my lungs are 40% smaller in size/80% smaller in volume than they were 6 weeks ago…..Doctor said its one of the most impressive responses he’s seen…..not spiking any footballs yet, but the news could not be better……thank you so much caring……flying home tomorrow

[roadrunner]

That is fabulous news! Certainly well-earned given what you went through to get this treatment. Did you discuss where it all goes from here? Is there an expectation that you’ll likely continue to see progressive benefit, or are you in uncharted waters? If the latter, are there next steps you can consider now, or are you in a holding pattern?

[prayingforccr]

That is fabulous news! Certainly well-earned given what you went through to get this treatment. Did you discuss where it all goes from here? Is there an expectation that you’ll likely continue to see progressive benefit, or are you in uncharted waters? If the latter, are there next steps you can consider now, or are you in a holding pattern?

Great questions.

I’ll be back.