GGT and CEA

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Bob1974
Posts: 2
Joined: Sun Jul 17, 2022 11:10 am

GGT and CEA

Postby Bob1974 » Sun Jul 17, 2022 12:12 pm

Hi all, I'm new here and UK based. DX Nov 2021, had high anterior resection followed by 4 cycles of Capox as one out of 40 nodes was found to be positive. For the past few blood tests my GGT levels have been raised and my CEA has been rising slowly but steadily - from 0.9 pre chemo to 1 during, 1.9 afterwards and 3 at last test (end of June, 3 months post chemo finishing). GGT at last test was 54 having gone up to 154 previously.

It's my understanding that the liver processes CEA so liver inflammation could account for rising CEA (hoping so!) but i just wondered if anyone else had slightly higher GGT levels and if they had an effect on your CEA?|

I did try to search to avoid duplicating topics but 'GGT' was unsearchable as too short!

TIA x

I_will_fight
Posts: 103
Joined: Mon Jun 29, 2020 3:38 pm

Re: GGT and CEA

Postby I_will_fight » Sun Jul 17, 2022 3:05 pm

Hi Bob,

It may not be quite the same scenario as yours, but I had normal CEA levels on DX and they went up during my 4 Capox cycles (from 0.9 to 2.4 at last cycle)

In parallel my liven enzimes also went up, and one of the several explanations I heard is the one you are venturing, liver cleans up CEA, so liver stress imparis the liver's ability to clean up CEA and therefore increases CEA in serum.

Javi.
46 yo male Spain
06/20 - 6cm T3N0M0 CC splenic flex
No liver mets, 3 and 4 mm lung dots (unlikely to be mets)
lymp 0/37
MSH6- other MMR+
KRAS mt G13D
V/LNI absent
PNI present
07/20 - hemicol surg, 13cm clear margins, optimistic surgn.
08/20 - CAPOX regime, 4 cycles.
11/20 - CAPOX completed. CAT scan: lesion in liver, suspect hemoangioma, no changes lung dots.
12/20 - Clean colonoscopy
02/21 - MRI liver lesion is nonspecific, stable.

I_will_fight
Posts: 103
Joined: Mon Jun 29, 2020 3:38 pm

Re: GGT and CEA

Postby I_will_fight » Sun Jul 17, 2022 3:08 pm

Also a trick for this forum

If you want to search for a small or common word, just put it beetween double quoutes, searching for "GGT" renders many results

And btw, welcome to the forum!

Javi
46 yo male Spain
06/20 - 6cm T3N0M0 CC splenic flex
No liver mets, 3 and 4 mm lung dots (unlikely to be mets)
lymp 0/37
MSH6- other MMR+
KRAS mt G13D
V/LNI absent
PNI present
07/20 - hemicol surg, 13cm clear margins, optimistic surgn.
08/20 - CAPOX regime, 4 cycles.
11/20 - CAPOX completed. CAT scan: lesion in liver, suspect hemoangioma, no changes lung dots.
12/20 - Clean colonoscopy
02/21 - MRI liver lesion is nonspecific, stable.

Bob1974
Posts: 2
Joined: Sun Jul 17, 2022 11:10 am

Re: GGT and CEA

Postby Bob1974 » Sun Jul 17, 2022 5:25 pm

Amazing Javi, thank you (on both counts!) xx


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