Page 1 of 1

Rectal Cancer 12 patients cured

Posted: Mon Jun 06, 2022 12:19 pm
by Rikimaroo
Interesting guys!! This could be huge.

https://www.yahoo.com/news/cancer-trial ... 46950.html

Re: Rectal Cancer 12 patients cured

Posted: Mon Jun 06, 2022 2:06 pm
by Dennyp
Very exciting news!

Re: Rectal Cancer 12 patients cured

Posted: Mon Jun 06, 2022 4:26 pm
by roadrunner
It’s good for Lynch and MSI generally, I think. But a key step is to bring this kind of result to those who are not in the small group that current immunotherapy targets.

I would add that this is one of the strategic dilemmas CRC patients face in the current environment. The current effective therapies for MSS can have decidedly negative effects on the immune system, including some that are permanent or semi-permanent. While the proper balance of anti-cancer and immunosuppressive effects is often achieved, I am mindful of the rapid advances in the immunotherapy field. It is very important to focus on exercise, diet, and overall health for these reasons. Not only does a healthy immune system help protect against progression generally, but it also keeps patients in the group would could derive benefit from what may be very rapid advances in this area in the near future.

I know it’s darn hard, but I am working diligently to improve diet for these reasons: maximizing plant proteins, minimizing sugar, minimizing carbs (more sugar), no more mammals for dinner, and no (or nearly no) alcohol. The exercise is fun, so that’s easy. May not matter in the end, but it just might, at that.

Re: Rectal Cancer 12 patients cured

Posted: Mon Jun 06, 2022 4:42 pm
by roadrunner
This comment from the article below stood out:

“Outside experts say that the study is still too small to change the way patients with mismatch repair deficiency are treated. ‘These results are cause for great optimism, but such an approach cannot yet supplant our current curative treatment approach. . ..’”

Really? 100% cure with little or no “sequelae” is not good enough? Yes, I understand that it’s a small study, and long term prospects are not certain, but any CRC patient with mismatch repair deficiencies/MSI would in my view be certifiable if they failed to start with a consult on this approach. Sometime medical science loses sight of the fact that to patients these things can seem somewhat urgent. :wink:

https://www.statnews.com/2022/06/05/wit ... y-patient/

Re: Rectal Cancer 12 patients cured

Posted: Tue Jun 07, 2022 8:08 am
by Rikimaroo
From my doctor's office

"Good morning,

This study is for patients with a certain mutation (MSI-H ) on the tumors, which will not apply in you case."

MSI has so many options but 85% of rectal is MSS, what the ****!!

Riki

Re: Rectal Cancer 12 patients cured

Posted: Tue Jun 07, 2022 10:59 am
by MadMed
It seems obvious now that SOC is shackling progress. I hate to be cynical but too many people have too much invested in SOC (careers, expertise etc..)

Even the lead on this clinical trial said:
“It is very hard to alter the standard of care,” Diaz said. “The whole standard-of-care machinery wants to do the surgery.”

I believe the same is true for chemo. Most oncologists shudder at the thought of trying something as simple as ctDNA. I always remind myself, to them it's losing a patient, to me, it's my life.

But it would be naive to only indict SOC, the pharma companies have their own politic. Keytruda was discovered in 2006, it was approved for CRC only in 2020. Between 2006 and 2010:
The development program for pembrolizumab was seen as high priority at Organon, but low at Schering and later Merck. In early 2010, Merck terminated development and began preparing to out-license it.

ref: https://en.wikipedia.org/wiki/Pembrolizumab

Meanwhile, how many people lost their lives ? MSI used to be a death sentence, i am glad it can be potentially cured without chemo/rad/surgeery!

Re: Rectal Cancer 12 patients cured

Posted: Tue Jun 07, 2022 12:50 pm
by Rikimaroo
MadMed - You are not being cynical thus the conundrum of cancer cure. Many people would lose jobs, billions of revenue would be lost and it would be a huge disrupt in the industry. It is an absolute shame that human lives are not as important vs dollars...at least I feel that way. I understand there are many different strands of cancer and its not easy to cure and perhaps the thought of those in employment of cancer treating positions would still keep there jobs to administer the so call cure (if it comes to be) might give us hope, but a shake up in the industry would happen nevertheless if there was a cure.

It hurts to think as a cancer patient your life is just a number and nothing more. I think my doctors care but the thought of there livelihood being hindered could pose cause for concern. It's a really nasty circling process.

Hope is so hard to grasp as a cancer patient :(

Chemo is so hard.

Riki

Re: Rectal Cancer 12 patients cured

Posted: Tue Jun 07, 2022 11:10 pm
by MikeManess
This offers hope .. good things are starting to happen. My medical oncologist once told me that he hopes cancer can become a re-occurring disease. Not to be cynical, but I think that's the hope of most cancer professionals. Something that is hailed as a cure would send shockwaves throughout the medical industry. While I have hope for this, I am taking a wait and see attitude.

Re: Rectal Cancer 12 patients cured

Posted: Thu Jun 09, 2022 4:59 am
by Nycomomohead
It is so hard to not be cynical. If you look at the small biotech sector, it has and is being pummeled on the capital markets. It is complex, but many promising platforms are abandoned, shopped to large pharma, but often lay dormant.

The approval processes in the States, also differ widely then other parts of the world.



MadMed wrote:It seems obvious now that SOC is shackling progress. I hate to be cynical but too many people have too much invested in SOC (careers, expertise etc..)

Even the lead on this clinical trial said:
“It is very hard to alter the standard of care,” Diaz said. “The whole standard-of-care machinery wants to do the surgery.”


ref: https://en.wikipedia.org/wiki/Pembrolizumab

Meanwhile, how many people lost their lives ? MSI used to be a death sentence, i am glad it can be potentially cured without chemo/rad/surgeery!