Rectal Cancer 12 patients cured

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Rikimaroo
Posts: 408
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Rectal Cancer 12 patients cured

Postby Rikimaroo » Mon Jun 06, 2022 12:19 pm

Interesting guys!! This could be huge.

https://www.yahoo.com/news/cancer-trial ... 46950.html
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

Dennyp
Posts: 39
Joined: Thu Oct 29, 2020 9:28 pm

Re: Rectal Cancer 12 patients cured

Postby Dennyp » Mon Jun 06, 2022 2:06 pm

Very exciting news!
5/19 IIIC sigmoid cancer 2/25 lymph nodes positive
5/19 surgery
7/19 FOLFOX 6 months
9/20 recurrence to single lymph node
10/20 FOLFIRI 5 rounds
1/21 surgery to remove lymph node
4/21 CT NED
8/21 CT NED
11/21 CT NED
2/22 CT NED
5/22 CT NED

roadrunner
Posts: 258
Joined: Sun Jan 12, 2020 8:46 pm

Re: Rectal Cancer 12 patients cured

Postby roadrunner » Mon Jun 06, 2022 4:26 pm

It’s good for Lynch and MSI generally, I think. But a key step is to bring this kind of result to those who are not in the small group that current immunotherapy targets.

I would add that this is one of the strategic dilemmas CRC patients face in the current environment. The current effective therapies for MSS can have decidedly negative effects on the immune system, including some that are permanent or semi-permanent. While the proper balance of anti-cancer and immunosuppressive effects is often achieved, I am mindful of the rapid advances in the immunotherapy field. It is very important to focus on exercise, diet, and overall health for these reasons. Not only does a healthy immune system help protect against progression generally, but it also keeps patients in the group would could derive benefit from what may be very rapid advances in this area in the near future.

I know it’s darn hard, but I am working diligently to improve diet for these reasons: maximizing plant proteins, minimizing sugar, minimizing carbs (more sugar), no more mammals for dinner, and no (or nearly no) alcohol. The exercise is fun, so that’s easy. May not matter in the end, but it just might, at that.
7/19: Rectal cancer: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (side effects/reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
CT 3/22: Clear
Thoracic CT 5/19/22 Clear
6/20/22 TAE rectal polyp benign

roadrunner
Posts: 258
Joined: Sun Jan 12, 2020 8:46 pm

Re: Rectal Cancer 12 patients cured

Postby roadrunner » Mon Jun 06, 2022 4:42 pm

This comment from the article below stood out:

“Outside experts say that the study is still too small to change the way patients with mismatch repair deficiency are treated. ‘These results are cause for great optimism, but such an approach cannot yet supplant our current curative treatment approach. . ..’”

Really? 100% cure with little or no “sequelae” is not good enough? Yes, I understand that it’s a small study, and long term prospects are not certain, but any CRC patient with mismatch repair deficiencies/MSI would in my view be certifiable if they failed to start with a consult on this approach. Sometime medical science loses sight of the fact that to patients these things can seem somewhat urgent. :wink:

https://www.statnews.com/2022/06/05/wit ... y-patient/
Last edited by roadrunner on Mon Jun 06, 2022 9:03 pm, edited 1 time in total.
7/19: Rectal cancer: Staged IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.; lung micronodule
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (side effects/reduced 70-75%)
neoadjuvant chemorad 11/19
4 rounds FOLFOX July-August 2020
ncCR 10/20; biopsies neg
TAE 11/20, tumor cells removed
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT nodule 1/22
CT 3/22: Clear
Thoracic CT 5/19/22 Clear
6/20/22 TAE rectal polyp benign

prayingforccr
Posts: 352
Joined: Sun Jun 28, 2020 4:44 pm

Re: Rectal Cancer 12 patients cured

Postby prayingforccr » Mon Jun 06, 2022 5:41 pm

And yet 5FU, discovered in 1957, remains SOC.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months
7/22 beginning sbrt and immunotherapy

Rikimaroo
Posts: 408
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Re: Rectal Cancer 12 patients cured

Postby Rikimaroo » Tue Jun 07, 2022 8:08 am

From my doctor's office

"Good morning,

This study is for patients with a certain mutation (MSI-H ) on the tumors, which will not apply in you case."

MSI has so many options but 85% of rectal is MSS, what the ****!!

Riki
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

MadMed
Posts: 146
Joined: Sun May 02, 2021 5:52 pm
Location: Massachusetts

Re: Rectal Cancer 12 patients cured

Postby MadMed » Tue Jun 07, 2022 10:59 am

It seems obvious now that SOC is shackling progress. I hate to be cynical but too many people have too much invested in SOC (careers, expertise etc..)

Even the lead on this clinical trial said:
“It is very hard to alter the standard of care,” Diaz said. “The whole standard-of-care machinery wants to do the surgery.”

I believe the same is true for chemo. Most oncologists shudder at the thought of trying something as simple as ctDNA. I always remind myself, to them it's losing a patient, to me, it's my life.

But it would be naive to only indict SOC, the pharma companies have their own politic. Keytruda was discovered in 2006, it was approved for CRC only in 2020. Between 2006 and 2010:
The development program for pembrolizumab was seen as high priority at Organon, but low at Schering and later Merck. In early 2010, Merck terminated development and began preparing to out-license it.

ref: https://en.wikipedia.org/wiki/Pembrolizumab

Meanwhile, how many people lost their lives ? MSI used to be a death sentence, i am glad it can be potentially cured without chemo/rad/surgeery!
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
NED as of 4/06 CT/MRI/sigmoidoscopy
On W&W 04/06/2022

Rikimaroo
Posts: 408
Joined: Tue Dec 20, 2016 8:48 pm
Location: Florida

Re: Rectal Cancer 12 patients cured

Postby Rikimaroo » Tue Jun 07, 2022 12:50 pm

MadMed - You are not being cynical thus the conundrum of cancer cure. Many people would lose jobs, billions of revenue would be lost and it would be a huge disrupt in the industry. It is an absolute shame that human lives are not as important vs dollars...at least I feel that way. I understand there are many different strands of cancer and its not easy to cure and perhaps the thought of those in employment of cancer treating positions would still keep there jobs to administer the so call cure (if it comes to be) might give us hope, but a shake up in the industry would happen nevertheless if there was a cure.

It hurts to think as a cancer patient your life is just a number and nothing more. I think my doctors care but the thought of there livelihood being hindered could pose cause for concern. It's a really nasty circling process.

Hope is so hard to grasp as a cancer patient :(

Chemo is so hard.

Riki
RC T3N1M0 12/16
MSS - NRAS Mutation
Chemo Rad, CCR - W&W 5/2017
Recurrence 11/2017
CT Scan 11/2017 Liver Met 5.5cm Stable, Stage IV
LAR/Liver Resect 4/2018
Reversal 10/18
CEA highest 500, lowest .8 throughout process, waiting for latest
Recurrence left vesical/pelvic sidewall - 10/7/2019 resect perm bag,
CEA rise Feb/May 3.7, 8.8, 30, Recurrence in Pelvic
CEA 40 right now, but was 57, so folfiri to beat it back down.
Lots of chemo for the past 4 years.

User avatar
MikeManess
Posts: 90
Joined: Fri Apr 01, 2016 3:56 pm
Location: Forney, Texas

Re: Rectal Cancer 12 patients cured

Postby MikeManess » Tue Jun 07, 2022 11:10 pm

This offers hope .. good things are starting to happen. My medical oncologist once told me that he hopes cancer can become a re-occurring disease. Not to be cynical, but I think that's the hope of most cancer professionals. Something that is hailed as a cure would send shockwaves throughout the medical industry. While I have hope for this, I am taking a wait and see attitude.
3/11/16 Colonoscopy - 9 benign polyps, 1 large cancerous tumor in right ascending colon
4/19/16 Right colectomy
6/3/16 Two liver spots detected, added Avastin to Folfox
12/20/16 Liver surgery. Pathology shows no active cancer cells
6/7/17 Final chemo
12/5/17 Port removed
05/23/18 Liver tumor discovered in scans
04/04/19 Radiation treatment
08/15/19 Additional radiation treatment
08/21/19 NED again

Nycomomohead
Posts: 28
Joined: Sat Oct 30, 2021 7:34 pm

Re: Rectal Cancer 12 patients cured

Postby Nycomomohead » Thu Jun 09, 2022 4:59 am

It is so hard to not be cynical. If you look at the small biotech sector, it has and is being pummeled on the capital markets. It is complex, but many promising platforms are abandoned, shopped to large pharma, but often lay dormant.

The approval processes in the States, also differ widely then other parts of the world.



MadMed wrote:It seems obvious now that SOC is shackling progress. I hate to be cynical but too many people have too much invested in SOC (careers, expertise etc..)

Even the lead on this clinical trial said:
“It is very hard to alter the standard of care,” Diaz said. “The whole standard-of-care machinery wants to do the surgery.”


ref: https://en.wikipedia.org/wiki/Pembrolizumab

Meanwhile, how many people lost their lives ? MSI used to be a death sentence, i am glad it can be potentially cured without chemo/rad/surgeery!
Spouse, DX, 49F - Rectal Stage 1 - T2NOMO - 2CM - 7.8 from AV.
10.29.21 Rectal tumor 2cm, 10cm from AV | colonoscopy
11.01.21 Biospy - Malignant - adenocarcinoma
11.03.21 First consultation with Surgeon & Onc
11.04.21 CBC blood work looked good. CEA at 1.1
11.05.21 CT Scan. Good, no sign of spread. Precautionary Liver MRI scheduled.
11.09.21 MRI Pelvis. MRI Liver.
11.09.21 Staged as Stage 1. T2NOMO - 2CM - 7.8 from AV.


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