Dostarlimab for MSI

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MadMed
Posts: 216
Joined: Sun May 02, 2021 5:52 pm
Location: Massachusetts

Dostarlimab for MSI

Postby MadMed » Sun Jun 05, 2022 3:38 pm

This looks good:
https://www.nejm.org/doi/full/10.1056/NEJMoa2201445

The NY Times article:
https://www.nytimes.com/2022/06/05/heal ... bitor.html

It's a small number, but 100% CCR is unheard of.

I unfortunately am not MSI but i would be thrilled if they got something working for MSI!
Last edited by MadMed on Sun Jun 05, 2022 8:36 pm, edited 2 times in total.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
NED as of 4/06 CT/MRI/sigmoidoscopy
On W&W 04/06/2022
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Siti
Posts: 269
Joined: Thu Aug 01, 2019 10:58 am

Re: Dostarlimab for MSI

Postby Siti » Sun Jun 05, 2022 8:13 pm

I woke up to this news earlier this morning too..amazing! I hope they accelerate the next trial with more patients since the results are so promising!
DH (54) DX on 5/7/19
Sigmoid|G3|LN:30/31|MSS|WT KRAS, NRAS, BRAF
7/19 PET distant LN para-aorta neck hip (0.5-1.5cm)
7/19 Lap resection
26/8 to 20/12/19 CAPEOX+Bev 7x
6/11/19 CT 3 cycle LN shrunk
1/20 Cap+Bev
4/20 TS-1+Bev due to bad HFS
NED 4 years
8/23 PET recurrence chest LN growing since Feb. CEA May(4.5>5.1>5.9)
9/23 Stopped Bev, CEA Sept(8.7) Radio 17x
11/23 PET 1+ supraclavicular LN, CEA (3.4>2.5)
12/23 Lymphadenectomy
1/24 Narrow margins, 1/5 +LN, 1.4cm +tissue, TMB (19)
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MadMed
Posts: 216
Joined: Sun May 02, 2021 5:52 pm
Location: Massachusetts

Re: Dostarlimab for MSI

Postby MadMed » Tue Jun 07, 2022 10:41 am

Yes, there's evidence that MSS tumors with high TMB respond to immunotherapy:
https://ascopost.com/news/february-2021/responses-to-anti-pd-1pd-l1-immunotherapy-in-patients-with-mss-solid-tumors-and-high-tumor-mutational-burden/

TMB is rarely considered or determined, but it's becoming important.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
NED as of 4/06 CT/MRI/sigmoidoscopy
On W&W 04/06/2022
Top
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