I have decided to post to this forum, newly diagnosed and very discouraged, I come here often to read other's advice or words of encouragement. I have not handled the diagnosis well, and the stage 4 sent me off the deep edge. I am so inspired by reading everyone's battles so trying to buck up. I have gone through 3 cycles of Folfox 6 with the anticipation of doing 6 infusions before liver and rectal resection surgeries, then clean up with another 6 cycles. The liver surgeon told me the mets are resectable initially, but he would like to see some shrinking, especially with the met near the portal vein. Cycle 3 left my WBC low, so an injection of neulasta last cycle, and a slight reduction in bolus 5FU. Went for the fourth treatment and liver enzyme had shot up to ALT 319/AST 127, bilibrium is at .5. Dr would not treat me, sent me for US looking for blockages, none noted, and initially visible liver mets were not visible (I understand ultrasound won't pick up mets as well as CT). Going for CT/MRI next week to see what is going on with the liver. I worry about progression of disease. (I tend to always look at things worst case scenario)
My question, is such a large jump in liver enzymes a sign that I will not be able to do chemo? I need the liver healthy to have the resection, is the fluctuations due to the oxy, do these enzymes tend to go back down? I am learning that the chemo affects all differently, and these treatments don't always go without some complication. My fears are that my body will not tolerate chemo which will leave me with no options. Any advice on fluctuating liver enzymes?
2/22 - Dx with stage 4 rectal cancer 4cm on/1cm from AV - age 60
T4, poorly diff., EMVI + mesolectal nodes suspicious, extramesorectal nodes neg. MSS
3/22 - CT/MRI 2 liver mets 2.1 cm and 1 smaller close to hepatic vein
Tiny <4mm lung nodules noted.
3/22 Infusion - plan 6 treat. Folflox 6, liver res., chemoradiation, rectal surgery 6 more cycles Folfox
5/5 - CT/MRI, lung nodules no change, liver lesions red. to 1.1 and .9cm, rectal tumor/suspicious lymph node red..