Whole genome sequencing

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saltygirl
Posts: 59
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Whole genome sequencing

Postby saltygirl » Tue Apr 26, 2022 5:47 pm

Whole genome sequencing. Is it worth it? What is your experience?

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: Whole genome sequencing

Postby prayingforccr » Tue Apr 26, 2022 9:06 pm

Do you mean a full breakdown of your tumor including mutations?

https://www.illumina.com/areas-of-inter ... e-seq.html

Or are you hoping for this to be more of a predictive tool?

I know EXACTLY what my mutations are as I volunteered at sloan kettering for analysis.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.

saltygirl
Posts: 59
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Re: Whole genome sequencing

Postby saltygirl » Tue Apr 26, 2022 9:10 pm

No, genetic testing. My friend who is a physician is recommending it. For about $3,000 I would get full genetic genome sequencing done - not just cancer but all possible conditions. It would stay in a database. And the company would send me annul update if new genes are discovered. I am asking my onco about it as well.

saltygirl
Posts: 59
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Re: Whole genome sequencing

Postby saltygirl » Tue Apr 26, 2022 9:12 pm

I know what my tumor mutations were. Crazy but I have braf and cras together. That was believed to be exclusive. It’s very unusual to have both.

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: Whole genome sequencing

Postby prayingforccr » Tue Apr 26, 2022 9:24 pm

saltygirl wrote:No, genetic testing. My friend who is a physician is recommending it. For about $3,000 I would get full genetic genome sequencing done - not just cancer but all possible conditions. It would stay in a database. And the company would send me annul update if new genes are discovered. I am asking my onco about it as well.


For me, it would depend upon my age and whether or not I had children who needed me.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.

Rock_Robster
Posts: 676
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Whole genome sequencing

Postby Rock_Robster » Wed Apr 27, 2022 1:05 am

I’m not sure if it’s the same thing, but I had genetic testing done which looked at some 70 known mutations and genetic changes which could be linked to increased cancer risk. Didn’t find anything potentially pathological. I mainly did it as my wife and I were considering having kids via IVF, and we would have had the option to screen/select out genetic conditions. The testing took a while but was free as part of a study.
40M Australia
2018 Dx RC, 12cm high
Mod diff, EMVI, LVI. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14; then ~2. Nov-21: 5.4
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic IMRT radiation
7/19 ULAR & ileo, 1/27 LN
8/19 Liver lesion
8/19 FOLFOX, FOLFOXIRI, FOLFIRI x7
12/19 Liver resection
NED
2/20 Ileo reversed
11/21 Liver met & celiac node; 2-3 tiny lung things, indeterminate
12/21 PVE
3/22 Nodal spread & 3 liver lesions. Lymphadenectomy
4/22 Liver SBRT x 5

saltygirl
Posts: 59
Joined: Sun Feb 07, 2021 4:46 pm
Facebook Username: Salty.girl

Re: Whole genome sequencing

Postby saltygirl » Wed Apr 27, 2022 7:54 am

Hi,
I had genetic testing done. This is different.
DNA sequence of an organism's genome. It has been offered to determine an individual’s risk of future disease based on a subject’s DNA mismatch from “normal.” However, other than relatively rare monogenic diseases (caused by one gene), most illnesses and traits result from multiple gene interactions coupled with environmental and lifestyle.


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