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Interesting Article/Trial
Posted: Tue Apr 19, 2022 4:18 pm
by roadrunner
This looks promising. I read the piece on the trial linked here, and they seem to be doing liver primaries at present, but the concept seems more broadly applicable (with certain limitations discussed in this piece or the linked article). In any case, there are a number of “mechanical” interventions coming soon that look really promising. Thought I’d share in case some folks haven’t seen this.
https://news.umich.edu/tumors-partially ... come-back/
Re: Interesting Article/Trial
Posted: Wed Apr 20, 2022 9:48 am
by Claudine
I really think this decade is going to see tremendous improvements in the treatment of mCRC!
Re: Interesting Article/Trial
Posted: Wed Apr 20, 2022 1:56 pm
by roadrunner
I agree. One part of good cancer care is often keeping an eye on this stuff, and that falls to patients and caregivers in the end because doctors have too many patients with diverse circumstances to reliably keep an eye on this for each of us. Depending on timing, strategic decisions now may open up, or foreclose, opportunities that may be available in even just a few years. I think many cancer doctors and patients accept the status quo because treatment advances in many cancers have been glacial. (For CRC at least, the main drug (5FU) was discovered in 1957(!)) But as Bob Dylan said, “the times they are (finally) a-changin’.
I think it’s important not to think *solely* about odds and options in light of today’s SOC, but always to consider the potential value of extending things to perhaps grab one of these opportunities as they become available, even if only through trials.
Re: Interesting Article/Trial
Posted: Fri Apr 22, 2022 7:48 am
by Peregrine
Thank you for sharing this article.
Re: Interesting Article/Trial
Posted: Fri Apr 22, 2022 10:02 pm
by Nor Cal
Thanks for posting. Interesting stuff. Makes me want to turn up my stereo and tell the neighbors "doctor's orders!"
Re: Interesting Article/Trial
Posted: Sat Apr 23, 2022 6:01 am
by rp1954
That is a very interesting article - implying potential for "sono-immunosurgery".
One thing is that critters often have some differences in immune components from even healthy people, much less patients with severe cancer. Patients might also need to measure, preserve (ahem), and substantially rev up their immune functions.
If I were inoperable at a location, I'd certainly be looking at this, with the potentially lower sonic tx levels too, and how to highly rev up my immune system with "simple" nutrients and techniques even more. Most other treatments in the non-surgical, physical abalation category (e.g. SBRT, electroporation, RFA) are often too injurious, incomplete, inflammatory and/or immune suppressive to produce a locally curative result.
PS Social, inertial, economic and political considerations often prevent the efficient, fully intelligent application of many discoveries. 5FU (1957) is still a suboptimally applied wonder drug. Many lessons that should have been learned decades are ignored, misunderstood, forgotten and/or even deprecated. This is one reason my wife was able to handle long term chemo so well - I could pick up a cheap 5FU drug like UFT , find or figure out and apply 5-6 of those unused lessons. One particularly nasty onc, laughed at me and said I would burn up my wife's bone marrow with UFT-LV. After the initial shock of this prediction, I realized that she probably hadn't hurdled even one of those 5-6 speed bumps in 25+ years - none were "std" practice, rather than obtained through the power of just reading, much less critical reading and thinking.
Re: Interesting Article/Trial
Posted: Wed May 04, 2022 3:48 pm
by beach sunrise
Hmmm, sounds like a upscale Rife treatment?
Sounds promising.