Interesting Article/Trial

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roadrunner
Posts: 240
Joined: Sun Jan 12, 2020 8:46 pm

Interesting Article/Trial

Postby roadrunner » Tue Apr 19, 2022 4:18 pm

This looks promising. I read the piece on the trial linked here, and they seem to be doing liver primaries at present, but the concept seems more broadly applicable (with certain limitations discussed in this piece or the linked article). In any case, there are a number of “mechanical” interventions coming soon that look really promising. Thought I’d share in case some folks haven’t seen this.


https://news.umich.edu/tumors-partially ... come-back/
7/19: Rectal cancer: Staged as IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; biopsies negative
TAE 11/20, tumor cells removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT for remaining nodule 1/22
CT 3/22: Clear

Claudine
Posts: 680
Joined: Tue Mar 12, 2019 2:41 pm
Location: Montana

Re: Interesting Article/Trial

Postby Claudine » Wed Apr 20, 2022 9:48 am

I really think this decade is going to see tremendous improvements in the treatment of mCRC!
Wife of Dx 04/18 (51 yo). MSS, KRAS G12A, no primary
Lytic met L4 vertebrae, EBRT 04/18, SBRT 02/19
Resect small intestine 05/18 (no cancer - Crohn's)
Failed adjuvant Xelox ; Folfiri + Avastin 03/19 to 01/20
6.7 cm left adrenal mass 03/19, successful resection 02/20
Multiple small lung nodules (03/19) now gone/calcified
L3-L4-L5 fusion surgery and partial corpectomy 05/20
CEA since 03/19: high 81.1, low 3.2, now 66
MRI 2/11/22: rectal adenocarcinoma pT3 pN0 stage 2A
LAR surgery April 11

roadrunner
Posts: 240
Joined: Sun Jan 12, 2020 8:46 pm

Re: Interesting Article/Trial

Postby roadrunner » Wed Apr 20, 2022 1:56 pm

I agree. One part of good cancer care is often keeping an eye on this stuff, and that falls to patients and caregivers in the end because doctors have too many patients with diverse circumstances to reliably keep an eye on this for each of us. Depending on timing, strategic decisions now may open up, or foreclose, opportunities that may be available in even just a few years. I think many cancer doctors and patients accept the status quo because treatment advances in many cancers have been glacial. (For CRC at least, the main drug (5FU) was discovered in 1957(!)) But as Bob Dylan said, “the times they are (finally) a-changin’.

I think it’s important not to think *solely* about odds and options in light of today’s SOC, but always to consider the potential value of extending things to perhaps grab one of these opportunities as they become available, even if only through trials.
7/19: Rectal cancer: Staged as IIIA, T2N1M0
approx 4.25 cm, low/mid rectum, mod. well diff.
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; biopsies negative
TAE 11/20, tumor cells removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
VATS 12/8/21 sub-pleural met 7mm.
SBRT for remaining nodule 1/22
CT 3/22: Clear

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Peregrine
Posts: 41
Joined: Tue Mar 01, 2022 1:18 am

Re: Interesting Article/Trial

Postby Peregrine » Fri Apr 22, 2022 7:48 am

Thank you for sharing this article.

prayingforccr
Posts: 317
Joined: Sun Jun 28, 2020 4:44 pm

Re: Interesting Article/Trial

Postby prayingforccr » Fri Apr 22, 2022 1:46 pm

Where has all the money gone that all they offer is a treatment from 1957?

Answer: Administrators

I don’t know how cancer professionals can offer these treatments (which do not work) and not feel remorse and shame.
11/19: colonoscopy
12/19: diagnosed with stage 3 rectal cancer 6+cm tumor
1-3/20: 20 sessions of radiation, mon-fri capecetibine+clinical trial drug m3814
7/20: 8 treatmentsFOLFOX
11/20: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
5/21: Multiple lung nodules (3-6mm) on ct scan
10/21: md anderson gives me 1 year without treatment/3 years with folfiri/avastin (refused)
3/22 No growth in nodules 6 months…..most showing cavitation.

Nor Cal
Posts: 53
Joined: Sun Dec 06, 2020 8:18 pm

Re: Interesting Article/Trial

Postby Nor Cal » Fri Apr 22, 2022 10:02 pm

Thanks for posting. Interesting stuff. Makes me want to turn up my stereo and tell the neighbors "doctor's orders!" :D
Dx June 2020, stage IV, w liver mets in both lobes. M, age 50. Right-sided colon tumor. BRAF mutation. CEA 120
July 2020 - Present: 30 cycles chemo (All the various 5-FU regimens)
December 2020 - February 2021 Y90 Radioembolization, Chemoembolization x2

rp1954
Posts: 1592
Joined: Mon Jun 13, 2011 1:13 am

Re: Interesting Article/Trial

Postby rp1954 » Sat Apr 23, 2022 6:01 am

That is a very interesting article - implying potential for "sono-immunosurgery".
One thing is that critters often have some differences in immune components from even healthy people, much less patients with severe cancer. Patients might also need to measure, preserve (ahem), and substantially rev up their immune functions.

If I were inoperable at a location, I'd certainly be looking at this, with the potentially lower sonic tx levels too, and how to highly rev up my immune system with "simple" nutrients and techniques even more. Most other treatments in the non-surgical, physical abalation category (e.g. SBRT, electroporation, RFA) are often too injurious, incomplete, inflammatory and/or immune suppressive to produce a locally curative result.

PS Social, inertial, economic and political considerations often prevent the efficient, fully intelligent application of many discoveries. 5FU (1957) is still a suboptimally applied wonder drug. Many lessons that should have been learned decades are ignored, misunderstood, forgotten and/or even deprecated. This is one reason my wife was able to handle long term chemo so well - I could pick up a cheap 5FU drug like UFT , find or figure out and apply 5-6 of those unused lessons. One particularly nasty onc, laughed at me and said I would burn up my wife's bone marrow with UFT-LV. After the initial shock of this prediction, I realized that she probably hadn't hurdled even one of those 5-6 speed bumps in 25+ years - none were "std" practice, rather than obtained through the power of just reading, much less critical reading and thinking.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

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beach sunrise
Posts: 647
Joined: Thu Mar 05, 2020 7:14 pm

Re: Interesting Article/Trial

Postby beach sunrise » Wed May 04, 2022 3:48 pm

Hmmm, sounds like a upscale Rife treatment?
Sounds promising.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"


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