One Year Cancer-versery

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CancerBum21
Posts: 29
Joined: Fri Feb 26, 2021 6:27 am

One Year Cancer-versery

Postby CancerBum21 » Fri Feb 18, 2022 3:07 pm

Hey Y'all, just wanted to post on here and say I made it through the past 12 months. It's been a while ride that for sure. Lots of highs and lows -- Surgery, Chemo, Rad & Chemo, new baby, finished my MBA, many scans, pandemic, diagnosed with hypothyroidism, and lots of other mundane cancer stuff.

Just had my colonoscopy today and so far NED. Back to running 5k's, got 3rd in the mens on my last one, not sure if it count cause only 5 guys ran it and about 500 women. But hey work smart not hard. :-) I'm in the final round of interview for a new job. I think going back to work will hopefully be the end cap to this journey for me, but we will see. To be honest applying for jobs has been harder than chemo for me.

Does anyone know how to interrupt Natera's Signatera™ test results. Right now it says 0 detection and 0 level. Which is all good. But for people who have a reoccurrence how long was it 0 before it started to rise? Or if it's 0 are you pretty much good to go? --> trying to figure out if having another baby is a good idea and if so when.
34/M
DX:(Rectal Cancer) 2/15/21
Stage: T1N0M0
TAMIS Surgery 3/10/21
Pathology: T1NxM0 - LIV positive, 1/1 lymph positive Stage IIIA
FOLFOX 6 rounds
Radation & Xelota 5 weeks

Rock_Robster
Posts: 1027
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: One Year Cancer-versery

Postby Rock_Robster » Fri Feb 18, 2022 8:07 pm

Congrats and thanks for the update!

I found this on Signatera testing for CRC for stages I-III.

“After resection, 80% of patients with detectable ctDNA experienced disease recurrence, as compared with 13% of patients with undetectable ctDNA, translating to a significant 11-fold increase in the risk for relapse (P < .0001). Similarly, after the completion of adjuvant chemotherapy, 83% of patients with detectable ctDNA relapsed, as compared with 12% of patients with undetectable ctDNA (P < .0001). This translated into a 12-fold increase in the risk for relapse”.

I’m not sure if I’m doing bad science and dodgy maths here by mixing candidate pools (actually I’m pretty sure I am), but I believe recurrence rates for stage III overall (including 3b, 3c etc) are in the order of around 30%. So with a negative ctDNA test you could argue your recurrence risk has dropped to 12-13%. Of course as a stage III patient you’re probably on the higher end of the risk spectrum anyway in Signatera test pool, but as a IIIa patient you’d be on the lower end of the stage III recurrence risk stats.

I think all that we can really conclude is that a negative test result is a very encouraging sign, and your recurrence risk is probably relatively low in the scheme of cancers. Unfortunately population median data isn’t much help in predicting individual outcomes. Of course you’re an experiment of 1 and hence the outcome is binary - either you will recur or you won’t, but if you were a horse and we were at the track I’d definitely be putting my money on you.

Best of luck!
Rob
Last edited by Rock_Robster on Sat Feb 19, 2022 6:16 pm, edited 1 time in total.
41M Australia
2018 Dx RC
G2 EMVI LVI, 4 liver mets
pT3N1aM1a Stage IVa MSS NRAS G13R
CEA 14>2>32>16>19>30>140>70
11/18 FOLFOX
3/19 Liver resection
5/19 Pelvic IMRT
7/19 ULAR
8/19 Liver met
8/19 FOLFOX, FOLFOXIRI, FOLFIRI
12/19 Liver resection
NED 2 years
11/21 Liver met, PALN, lung nodules
3/22 PVE, lymphadenectomy, liver SBRT
10/22 PALN SBRT
11/22 Liver mets, peri nodule. Xeloda+Bev
4/23 XELIRI+Bev
9/23 ATRIUM trial
12/23 Modified FOLFIRI+Bev
3/24 VAXINIA (CF33 + hNIS) trial

DarknessEmbraced
Posts: 3816
Joined: Sat Nov 01, 2014 4:54 pm
Facebook Username: Riann Fletcher
Location: New Brunswick, Canada

Re: One Year Cancer-versery

Postby DarknessEmbraced » Sat Feb 19, 2022 9:22 am

Congratulations! :D
Diagnosed 10/28/14, age 36
Colon Resection 11/20/14, LAR (no illeo)
Stage 2a colon cancer, T3NOMO
Lymph-vascular invasion undetermined
0/22 lymph nodes
No chemo, no radiation
Clear Colonoscopy 04/29/15
NED 10/20/15
Ischemic Colitis 01/21/16
NED 11/10/16
CT Scan moved up due to high CEA 08/21/17
NED 09/25/17
NED 12/21/18
Clear colonoscopy 09/23/19
Clear 5 year scans 11/21/19- Considered cured! :)


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