My Current Protocol——-All Thoughts/Criticism Welcomed

[prayingforccr]

All of the lymph nodes indicated drain the lungs

[prayingforccr]

Feeling much better after a short meeting with Dr Chachoua

Immunotherapy/sbrt to begin in July

Goal is remission.

[Claudine]

That's great, this looks like a very promising approach, I really hope it works for you!

[prayingforccr]

“ I have been fortunate to successfully converge my radiobiology and clinical research interests in the care of many cancer patients. Specifically, in the past decade our group has demonstrated that local radiotherapy can contribute to immune rejection of cancer: in the presence of immune checkpoint blockade (anti-CTLA-4, anti-PDL-1) the irradiated tumor becomes an immunogenic hub, similar to a vaccine. Consistently some patients with metastatic tumors can then reject metastasis that were not irradiated, a mechanism called "abscopal effect". The contribution of localized radiotherapy significantly enhances the success of modern immunotherapy, offering an additional application to radiation, a standard and accessible anti-cancer therapy. With immunotherapy acquiring an important role in the management of most cancer patients, it is very exciting to be able converge radiotherapy as a powerful adjuvant to this approach.” -Dr Silvia Formenti

[Peregrine]

“ I have been fortunate to successfully converge my radiobiology and clinical research interests in the care of many cancer patients. Specifically, in the past decade our group has demonstrated that local radiotherapy can contribute to immune rejection of cancer: in the presence of immune checkpoint blockade (anti-CTLA-4, anti-PDL-1) the irradiated tumor becomes an immunogenic hub, similar to a vaccine. Consistently some patients with metastatic tumors can then reject metastasis that were not irradiated, a mechanism called "abscopal effect". The contribution of localized radiotherapy significantly enhances the success of modern immunotherapy, offering an additional application to radiation, a standard and accessible anti-cancer therapy. With immunotherapy acquiring an important role in the management of most cancer patients, it is very exciting to be able converge radiotherapy as a powerful adjuvant to this approach.” -Dr Silvia Formenti

pfccr -
Thanks very much for posting this information about Dr. Formenti's cutting-edge research on radiotherapy and the abscopal effect. I have the feeling that this research topic will be of interest to a number of other members here.

Dr. Sylvia Formenti's publications

[prayingforccr]

“ I have been fortunate to successfully converge my radiobiology and clinical research interests in the care of many cancer patients. Specifically, in the past decade our group has demonstrated that local radiotherapy can contribute to immune rejection of cancer: in the presence of immune checkpoint blockade (anti-CTLA-4, anti-PDL-1) the irradiated tumor becomes an immunogenic hub, similar to a vaccine. Consistently some patients with metastatic tumors can then reject metastasis that were not irradiated, a mechanism called "abscopal effect". The contribution of localized radiotherapy significantly enhances the success of modern immunotherapy, offering an additional application to radiation, a standard and accessible anti-cancer therapy. With immunotherapy acquiring an important role in the management of most cancer patients, it is very exciting to be able converge radiotherapy as a powerful adjuvant to this approach.” -Dr Silvia Formenti

pfccr -
Thanks very much for posting this information about Dr. Formenti's cutting-edge research on radiotherapy and the abscopal effect. I have the feeling that this research topic will be of interest to a number of other members here.

Dr. Sylvia Formenti's publications

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351396/

https://www.frontiersin.org/articles/10 ... 29250/full

[beach sunrise]

Onc seems very up on CRC treatments.
Will you continur any supplements?

[prayingforccr]

Onc seems very up on CRC treatments.
Will you continur any supplements?

I am going to continue with the fenbendazole, black seed oil (will increase), curcumin, and vitamin e.

And the ivermectin.

My reading indicates any cbd/thc product is a huge no no when doing immunotherapy.

[Peregrine]

...My reading indicates any cbd/thc product is a huge no no when doing immunotherapy.

Yes indeed, and here are some of those references ...

"As with any complementary therapy, you should always talk with your oncologist. Complementary therapies can interact negatively with immunotherapy or chemotherapies and/or reduce their effectiveness.

May I ask why are you taking cannabis oil? What are hoping it will help? Were you hoping it would help the infection and inflammation?"
Reference: https://connect.mayoclinic.org/discussion/cannabis-oil-and-immunotherapy/

https://www.oncologynurseadvisor.com/home/cancer-types/general-oncology/cannabis-reduces-response-rate-to-immunotherapy-for-cancer/

https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/cannabis-cancer-use-decrease-immunotherapy-efficacy

[prayingforccr]

My feeling has been that when I restart treatment, that it is the beginning of the end.

[prayingforccr]

This is essentially what I am doing beginning in July:

https://clinicaltrials.gov/ct2/show/NCT04575922

Wow, this is run out of Mass General here in Boston and it seems to be at the cutting edge of treatment. It would be awesome if it worked for you like the other MSI trial. Please let us know how it goes.

I’m going to be doing 6 sessions of sbrt over a two week period.

The radiation is targeting just one of the lesions.

I am unsure of the schedule for the opdivo/yervoy, but I do know the first dose of opdivo will be given to me one day prior to my initial sbrt session, and will be ongoing.

I am going to continue with the fenbendazole, black seed oil (will increase), curcumin, and vitamin e.

And the ivermectin.

[roadrunner]

This is probably obvious given how much you research things, but since it’s clear that you need your immune response to be optimal for this to have its best chance to work, have you discussed with Dr. Formenti any immunosuppressive effects of any supplements/alternative therapies you are continuing and how best to optimize T cell production? Also, does she use proton radiation, or conventional radiotherapy?

[prayingforccr]

This is probably obvious given how much you research things, but since it’s clear that you need your immune response to be optimal for this to have its best chance to work, have you discussed with Dr. Formenti any immunosuppressive effects of any supplements/alternative therapies you are continuing and how best to optimize T cell production? Also, does she use proton radiation, or conventional radiotherapy?

Dr Chachoua stressed nothing steroidal was to be taken.

My reading indicates NO cbd/thc.

The others checkout as fine, but I will run it past both doctors.

The ivermectin is reported to turn cold tumors “hot” which would be very desirable in this instance.

Vitamin e https://www.mdanderson.org/newsroom/stu ... 38956.html

Curcumin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415504/

[roadrunner]

Sounds good. As you know, I am a proponent of the strategy of extending survival to take advantage of developing technologies/treatments (especially given how promising many of these are right now), and it’s clear that what you’re doing here is widely regarded as a very promising such treatment indeed. Some authorities regard it as analogous to the vaccine approach, another of the leading candidates. I wish you the best with it!

[prayingforccr]

Sounds good. As you know, I am a proponent of the strategy of extending survival to take advantage of developing technologies/treatments (especially given how promising many of these are right now), and it’s clear that what you’re doing here is widely regarded as a very promising such treatment indeed. Some authorities regard it as analogous to the vaccine approach, another of the leading candidates. I wish you the best with it!

Thanks, rr.

I really, really hope it works.

I’m not sure what to hope for, but when I asked Dr Chachoua if this could get me to remission his answer was “That’s why we’re doing this, dude”.

Dare to dream.

I haven’t seen anything encouraging with MSS and opdivo/yervoy, but there are currently clinical trials very similar to what I will be doing.

If this doesn’t work, off to CHIPSA

At that point, I will have done everything possible to my satisfaction, and Ill huff a bag full of nitrogen after an internalized farewell tour.
If it’s my time, it’s my time.