Is 6 cycles of Folfox enough?

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ktex
Posts: 1
Joined: Sun Nov 21, 2021 9:48 am
Location: DFW Texas

Is 6 cycles of Folfox enough?

Postby ktex » Sun Nov 21, 2021 3:27 pm

Hello all,
I start my first of six cycles of folfox on 12/1. I will ask my oncologist about this as well but everything I’m seeing online is a minimum of 8 cycles. Has anyone else only had 6 and was it successful?

I have stage IIIb CC, G2, 2/29 + LN.

Thank you
M 44yo DX 10/21
Stage IIIb CC, G2, 2/29 LN +
Sigmoid recection 10/21
Start Folfox 6 cycles on 12/1/21

roadrunner
Posts: 179
Joined: Sun Jan 12, 2020 8:46 pm

Re: Is 6 cycles of Folfox enough?

Postby roadrunner » Sun Nov 21, 2021 5:33 pm

I ended up having 8, though Oxi was pulled or limited for two. I had a lot of conversations with my team that suggested 6 was enough. I think I also saw studies indicating that 6 wasn’t different from 8 on many important measures, though I have only a vague memory there at this point (might be worth a look). I would add, though, that unless you have serious neuropathy issues or dangerous complications, my two cents is that you will feel better in the future if you finish the 8. I got a very big benefit from it, but I think most of the measurable benefit occurred in the first 4. It’s hard to say about “success.” That’s the reason for a conservative approach.
7/19: Rectal cancer: Initially staged as IIIA, T2N1M0
Initially approx 4.25 cm, low/mid rectum, mod. well diff. adenocarcinoma
8/22 -10/14 4 rounds FOLFOX neoadjuvant, 3 w/Oxiplatin (lots of side effects/reduced size est. 70-75%)
neoadjuvant chemorad 11/19
4 rounds of FOLFOX July-August 2020
ncCR found 10/20; multiple biopsies negative
TAE 11/20, small amount of tumor removed, lung nodules orig id’d 6/20 stable Nov 2020
Chest CT 3/30/21 small growth in 2 nodules (3 and 5mm)
Stable in 6/28 scan.


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