HFS symptoms

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MadMed
Posts: 54
Joined: Sun May 02, 2021 5:52 pm

HFS symptoms

Postby MadMed » Wed Nov 17, 2021 9:22 pm

How long after Xeloda for chemo radiation did you have HFS ? Does it go away ever ?
I’m dealing with Xeloda side effects and trying to figure out how long they last.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
Break before surgery scheduled 1/27/22

JJH
Posts: 324
Joined: Mon Apr 24, 2017 7:26 am

Re: HFS symptoms

Postby JJH » Wed Nov 17, 2021 10:20 pm

MadMed wrote:How long after Xeloda for chemo radiation did you have HFS ? Does it go away ever ?
I’m dealing with Xeloda side effects and trying to figure out how long they last.

The pain-related symptoms of HFS go away eventually, but there are other effects that are permanent. For example, the loss of fingerprints and the appearance of smooth fingertips is permanent. You will always have more trouble now with tasks that require finger dexterity, like turning pages in a book or separating sheets of paper or separating sheets of plastic or picking up small items like small screws, small nails, etc. These tasks require rough fingertip surfaces with ridges which you may no longer have and which will not grow back over time.

There are things you can do (or stop doing) to make things a little better:
https://coloncancersupport.colonclub.com/viewtopic.php?f=1&t=58447&p=469055#p469055
Last edited by JJH on Fri Nov 19, 2021 1:50 am, edited 1 time in total.
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

MadMed
Posts: 54
Joined: Sun May 02, 2021 5:52 pm

Re: HFS symptoms

Postby MadMed » Thu Nov 18, 2021 2:43 pm

Thanks JJH, i already can't click on the ipad or unlock it with my finger! :roll: I hope the tingling and pins and needles will abate soon.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
Break before surgery scheduled 1/27/22

User avatar
beach sunrise
Posts: 557
Joined: Thu Mar 05, 2020 7:14 pm

Re: HFS symptoms

Postby beach sunrise » Sat Nov 20, 2021 12:15 pm

I didn't have it and still don't but will say I have no fingerprints now.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

MadMed
Posts: 54
Joined: Sun May 02, 2021 5:52 pm

Re: HFS symptoms

Postby MadMed » Sat Nov 20, 2021 5:46 pm

I’d be ok with that if it erased the cancer too.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
Break before surgery scheduled 1/27/22

rp1954
Posts: 1588
Joined: Mon Jun 13, 2011 1:13 am

Re: HFS symptoms

Postby rp1954 » Wed Nov 24, 2021 1:35 pm

The best preventative of HFS from xeloda that I've heard of, is IV vitamin C.

In a Riordan Clinic case study, a IVC + xeloda patient who didn't have HFS symptoms went on vacation. After some missed IV vitamin C infusions, they began to have HFS a week or so later. The HFS went away when the IV vitamin C was resumed. Riordan Clinic patients also do take a number of supplements. Other xeloda patients have had this IVC benefit for HFS.

For long estalished post chemo HFS, dunno. Other supplements? maybe.
Your mileage may vary.
watchful, active researcher and caregiver for stage IVb/c CC. surgeries 4/10 sigmoid etc & 5/11 para-aortic LN cluster; 8 yrs immuno-Chemo for mCRC; now no chemo
most of 2010 Life Extension recommendations and possibilities + more, some (much) higher, peaking ~2011-12, taper to almost nothing mid 2018, mostly IV C

User avatar
beach sunrise
Posts: 557
Joined: Thu Mar 05, 2020 7:14 pm

Re: HFS symptoms

Postby beach sunrise » Sat Nov 27, 2021 1:51 pm

IVC is what I give credit to for not ever having HFS. I also use burts bees hand salve mixed with vitamin E oil and sometimes I use coconut oil + vitamin E oil every day.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"

MadMed
Posts: 54
Joined: Sun May 02, 2021 5:52 pm

Re: HFS symptoms

Postby MadMed » Sat Nov 27, 2021 7:02 pm

Thank you, I’ll try that.
52M DX: RC lower rectum, guessing now 2cm from AV 4/27/2021
T3N0M0 adenocarcinoma with signet ring cell features
Tumor size 30mm
Tumor grade: G3
Baseline CEA 1.0
MSI status: MSS pMMR
Started Folfox 5/12/2021
Switched to FOLFIRINOX from session 2. 8 rounds total.
CT+MRI tumor contained shrunk 80%, no spread to other organs.
CRT started xeloda + 28 days Radiation 9/27-11/04
Break before surgery scheduled 1/27/22

User avatar
beach sunrise
Posts: 557
Joined: Thu Mar 05, 2020 7:14 pm

Re: HFS symptoms

Postby beach sunrise » Sun Nov 28, 2021 10:25 pm

I hope it helps.
8/19 RC CEA 82.6 T3N0M0
Neoadj 5FU/rad 6 wk
High dose IVC 1 1/2 wks before surgery. Continue still twice a week
Surg 1/20 APR - margins T4bN1a IIIC G2 MSI- 1/20 LN+ LVI+ PNI-
pre cea 24/post 5.9
FOLFOX
7 rds 6-10 CEA 11.4 No more
7/20 CEA 11.1, 8.8
8/20 CEA 7.8
9/20 CEA 8.8, 9, 8.6
10/20 CEA 8.1
11/20 CEA 8's
12/20 CEA 8's & 9's
ADAPT+++ TM drug
MHL1+
PMS2+
MSH2+
MSH6+
POLD1 , KRAS Q61H
Chem-sens test NCI "Test failed, neo adj CR worked. Not enough ca cells to test"


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