The Colon Club

I am searching for patients who have had liver mets and used integrative, or not, treatments, had near complete responses from chemo and were able to gain NED or minimal disease control without resection. Does this exist?

You used "cured" in your subject line, which is quite unusual, but it happens.

Complete response or NED definitely exist. We've been aggressive in my treatment, and some good data has come out recently showing the survival benefit of using radioembolization and chemoembolization early on in the process. I have no identifiable lesions in my scans - not that I expect that it is gone.

I agree with Nor Cal… if “without surgery” can include things like ablation, radiation (SABR/SBRT or SIRT/Y90), IRE etc, then certainly yes. If you mean “with systemic chemotherapy alone” then that is quite unusual (although case reports do exist). Immunotherapy for MSI/MSS-H is another category as well.

We just got the bad news of liver spots. I am hoping he will be a candidate for RFA (I doubt they would do resection due to the lymphatic spread).

Complete responses to chemo are a few percent, maybe 5% at most, of patients, which isn't zero but isn't very good odds.

I had a resection but after Folfox and Vectibix, they could not find any viable cancer cells in the the liver biopsies that they took. They actually had a hard time finding one of the tumors. I had very small tumors and I think responded to the vectibix very well so I think I am a rare case.

Dave