Can liver mets be cured without surgery

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JB09
Posts: 19
Joined: Sun Nov 07, 2021 6:21 pm
Facebook Username: Jaime Baskin

Can liver mets be cured without surgery

Postby JB09 » Fri Nov 12, 2021 5:06 pm

I am searching for patients who have had liver mets and used integrative, or not, treatments, had near complete responses from chemo and were able to gain NED or minimal disease control without resection. Does this exist?

Nor Cal
Posts: 45
Joined: Sun Dec 06, 2020 8:18 pm

Re: Can liver mets be cured without surgery

Postby Nor Cal » Sat Nov 13, 2021 10:53 am

You used "cured" in your subject line, which is quite unusual, but it happens.

Complete response or NED definitely exist. We've been aggressive in my treatment, and some good data has come out recently showing the survival benefit of using radioembolization and chemoembolization early on in the process. I have no identifiable lesions in my scans - not that I expect that it is gone.
Dx June 2020, stage IV, w liver mets in both lobes. M, age 50. Right-sided colon tumor. BRAF mutation. CEA 120
July 2020 - November 2021 23 cycles chemo (FOLFOXIRI x9, FOLFIRI x12, 5-FU x2) + Avastin (discontinued Nov 2021)
December 2020 - February 2021 Radioembolization, Chemoembolization x2

Rock_Robster
Posts: 607
Joined: Thu Oct 25, 2018 5:27 am
Location: Brisbane, Australia

Re: Can liver mets be cured without surgery

Postby Rock_Robster » Sat Nov 13, 2021 11:07 pm

I agree with Nor Cal… if “without surgery” can include things like ablation, radiation (SABR/SBRT or SIRT/Y90), IRE etc, then certainly yes. If you mean “with systemic chemotherapy alone” then that is quite unusual (although case reports do exist). Immunotherapy for MSI/MSS-H is another category as well.
39M Australia
2018 Dx RC, 12cm high
Mod diff, EMVI+ LVI+. 4 liver mets
pT3N1aM1a Stage IVa. MSS NRAS G13R
CEA: Nov-18= 14; then 2.0 - 3.1. Nov-21: 5.4
11/18 FOLFOX x6
3/19 Liver resection
5/19 25x pelvic radiation
07/19 ULAR w ileo, 1/27 LN+
08/19 Liver spot
08/19 FOLFOX x1, FOLFOXIRI x1, FOLFIRI x5
12/19 Liver resection
02/20 Ileo reversed
03/20 NED (since Dec-19)
11/21 New liver lesion (2 lymph nodes?), maybe 4 very small (<2mm) lung things

catstaff
Posts: 177
Joined: Wed Mar 03, 2021 11:37 am

Re: Can liver mets be cured without surgery

Postby catstaff » Sun Nov 14, 2021 7:19 am

We just got the bad news of liver spots. I am hoping he will be a candidate for RFA (I doubt they would do resection due to the lymphatic spread).

Complete responses to chemo are a few percent, maybe 5% at most, of patients, which isn't zero but isn't very good odds.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-

Gravelyguy
Posts: 369
Joined: Thu Jul 05, 2018 6:03 pm

Re: Can liver mets be cured without surgery

Postby Gravelyguy » Sun Nov 14, 2021 9:33 am

I had a resection but after Folfox and Vectibix, they could not find any viable cancer cells in the the liver biopsies that they took. They actually had a hard time finding one of the tumors. I had very small tumors and I think responded to the vectibix very well so I think I am a rare case.

Dave
6/17 dx mRC t3n1m1 very low rectal tumor 2 liver Mets 1.3 cm and .9 cm

6/17 begin 4 rounds Folfox w/Vectibix
9/17 short course radiation
10/17 rectal and liver resection LAR with coloanal anastomosis (no rectum left)
11/17-3/18 8 rounds Folfox
6/18 still NED!! Takedown
8/28/18 still NED! CEA .8 new low for me
10/18/18 colonoscopy clear
12/12/18 CEA .9 still NED!
6/11/19 CEA 1.0
12/19/19 CEA 1.0 still NED!
6/17/20 CEA 1.1 still NED!
12/15/20 CEA 1.1still NED!

prayingforccr
Posts: 174
Joined: Sun Jun 28, 2020 4:44 pm

Re: Can liver mets be cured without surgery

Postby prayingforccr » Mon Nov 15, 2021 8:01 pm

Look into ablation.
Nov 2019: colonoscopy
Dec 2019: diagnosed with stage 3 rectal cancer 6+cm tumor
Jan-mar 2020: 20 sessions of radiation, mon-fri capecetibine, mon-fri clinical trial drug m3814
Apr 2020: tumor/scar 3.7cm
July 2020: began 8 treatmentsFOLFOX
August 2020: ct scan reveals scarbed reduced to 2.7cm CEA is 1.5
Nov 2020: Primary tumor had complete response. Possible tumor deposits on latest mri. Biopsy negative for cancer.
May 2021: Multiple lung nodules (3-6mm) on ct scan


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