Husbandworried wrote:Microsatalite status equivocal
Everything else was negative
Husbandworried wrote:.... Surgery October 2020, negative margins surgeon said 50/50 chance of cure oncologist said slightly better than 50/50...
boxhill wrote:Equivocal MSS/MSI? That's a new one on me. Seems to generally be a result of testing failure because of poor sample or something like that. Can you delve into that more? What was equivocal about it? Not sure about dMMR/pMMR? Something else? MSS with high TMB maybe?
Being responsive to immunotherapy would definitely be huge. If it were me I would insist on retesting with a fresh sample, and I would pay for it myself if necessary. It doesn't have to be Foundation One.
If the MSI test that they did was "equivocal" they could do another test with a different tissue sample, and they could use the same approach or the alternate approach to testing. In my opinion, there is no excuse to accept an "equivocal" finding. They should persevere until they get a good result that is unequivocal.
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