mucinous adenocarcenoma

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Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

mucinous adenocarcenoma

Postby Julia123 » Tue Nov 09, 2021 4:35 am

good afternoon, i'm from ukraine, i'm 29 years old, diagnosed on June 4, mucinous adenocarcenoma 3b, now completed the 7th course folfox / 12 tell me who faced this type of tumor? what am I missing in treatment? Maybe I need some other medications and DNA tests? sorry for bad english

-———————————-
04.06(jun)2021
Mucinous adenocarcinoma sigmoid cancer
( ICD-O-3: 8480/3)

pT3 pN1a(1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0.69

MMEp/MSS: MLH1+, PMS2+,MSH2+, MSH6+



09.06 extended resection (with abdominal wall)

28.07 Folfox6 - 12 cycles

24.09 magnetic resonance tomography- clear
Cea 2.2
8.11.2021 - 7 cycles n
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

User avatar
GrouseMan
Posts: 869
Joined: Mon Aug 12, 2013 12:30 pm
Location: SE Michigan USA

Re: mucinous adenocarcenoma

Postby GrouseMan » Tue Nov 09, 2021 1:10 pm

This link might be useful to you.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440160/

Its a subtype of Colon Cancer, Many people with Lynch Syndrome present I think with this. Its treated about the same as other Colon cancers, but might be a candidate for Checkpoint inhibitors due to its MSI status.

Good Luck

GrouseMan
DW 53 dx Jun 2013
CT mets Liver Spleen lung. IVb CEA~110
Jul 2013 Sig Resct
8/13 FolFox,Avastin 12Tx mild sfx, Ongoing 5-FU Avastin every 3 wks.
CEA: good marker
7/7/14 CT Can't see the spleen Mets.
8/16/15 CEA Up, CT new abdominal mets. Iri, 5-FU, Avastin every 2 wks.
1/16 Iri, Erbitux and likely Avastin (Trial) CEA going >.
1/17 CEA up again dropped from Trial, Mets growth 4-6 mm in abdomen
5/2/17 Failed second trial, Hospitalized 15 days 5/11. Home Hospice 5/26, at peace 6/4/2017

JJH
Posts: 324
Joined: Mon Apr 24, 2017 7:26 am

Re: mucinous adenocarcenoma

Postby JJH » Thu Nov 11, 2021 5:31 am

You might be able to find some useful information here:

https://www.mskcc.org/russian
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

boxhill
Posts: 756
Joined: Fri Apr 06, 2018 11:40 am

Re: mucinous adenocarcenoma

Postby boxhill » Fri Nov 12, 2021 2:39 am

Julia123's signature indicated that she is MSS, not MSI.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
6/20 Stop Key
All MRIs NED

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: mucinous adenocarcenoma

Postby Julia123 » Fri Nov 12, 2021 9:56 am

boxhill wrote:Julia123's signature indicated that she is MSS, not MSI.


Hi,
does this mean that a mutation test is not needed? I understand that this is not Lynch syndrome.
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

boxhill
Posts: 756
Joined: Fri Apr 06, 2018 11:40 am

Re: mucinous adenocarcenoma

Postby boxhill » Fri Nov 12, 2021 1:15 pm

Even though you are MSS you may still have mutations that significantly affect your treatment, so you should still get it. And, not to confuse the matter but important, if your tumor mutation burden is 12 or so, you may still be eligible for immunotherapy. In addition, there are trials going on that combine other drugs with immunotherapy.

From what I've read, this could be particularly important to those with mucinous tumors.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
6/20 Stop Key
All MRIs NED

JJH
Posts: 324
Joined: Mon Apr 24, 2017 7:26 am

Re: mucinous adenocarcenoma

Postby JJH » Sat Nov 13, 2021 12:44 am

Julia123 wrote:
boxhill wrote:Julia123's signature indicated that she is MSS, not MSI.

Hi,
does this mean that a mutation test is not needed? I understand that this is not Lynch syndrome.

In my opinion, a mutation test is not really needed unless you are Stage IV. If you ever become Stage IV due to a recurrence, then a KRAS/NRAS/BRAF mutation panel is needed in order to determine which therapy regimens will be available to you. But you might want to have the test done now anyway, just to see what your status would be. Also, you may want to do a more extensive mutation test that will provide a Tumor Mutation Burden (TMB) index, if these kinds of test panels are available in your area.

In the USA, the following therapy drugs are available for use by colorectal cancer patients. However, the ones in bold face type below will require the KRAS/NRAS/BRAF mutation tests to see if you qualify for them. You would qualify for all the rest except the ones for 'MSI-H only'. You don't qualify for the 'MSI-H' drugs since your tumor is not MSI-H.
Drugs used in colorectal cancer, with ther FDA approval dates
1962 5-FU (Fluorouracil Injection) - no restrictions
1998 Xeloda (Capecitabine) - no restrictions
2000 Camptosar (Irinotecan Hydrochloride) - no restrictions
2004 Avastin (Bevacizumab) - mCRC 1st line+
2004 Eloxatin (Oxaliplatin) - no restrictions
2004 Erbitux (Cetuximab) - mCRC 1st line+, KRAS wild type only
2006 Vectibix (Panitumumab) - mCRC 1st line+, KRAS wild type only
2012 Keytruda (Pembrolizumab) - mCRC 1st line, MSI-H only
2012 Zaltrap (Ziv-Aflibercept) - mCRC 2nd line,
2012 Stivarga (Regorafenib) - no restrictions
2014 Cyramza (Ramucirumab) - mCRC 2nd line
2015 Lonsurf (Trifluridine and Tipiracil Hydrochloride) - no restrictions
2017 Opdivo (Nivolumab) - mCRC 1st line+, MSI-H only
2018 Yervoy (Ipilimumab) - mCRC 1st line+, MSI-H only
2019 Zirabev (Bevacizumab.alt) - mCRC 1st line+
2020 Braftovi (Encorafenib) - mCRC, BRAF V600E only
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: mucinous adenocarcenoma

Postby Julia123 » Sat Nov 13, 2021 1:51 pm

thank you very much for the answers! I am very worried about recurrence
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

boxhill
Posts: 756
Joined: Fri Apr 06, 2018 11:40 am

Re: mucinous adenocarcenoma

Postby boxhill » Sat Nov 13, 2021 2:35 pm

Given that mucinous tumors don't typically respond well to conventional chemotherapy, genetic testing at an earlier stage seems wise to me. My oncologist has been having genetic testing done on all of his stage 3 patients for several years. It doesn't have to be Foundation One.
F, 64 at DX CRC Stage IV
3/17/18 blockage, r hemi
11 of 25 LN,5 mesentery nodes
5mm liver met
pT3 pN2b pM1
BRAF wild, KRAS G12D
dMMR, MSI-H
5/18 FOLFOX
7/18 and 11/18 CT NED
12/18 MRI 5mm liver mass, 2 LNs in porta hepatis
12/31/18 Keytruda
6/19 Multiphasic CT LNs normal, Liver stable
6/28/19 Pause Key, predisone for joint pain
7/31/19 Restart Key
9/19 CT stable
Pain: all fails but Celebrex
12/23/19 CT stable
5/19 MRI stable/NED
6/20 Stop Key
All MRIs NED

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: mucinous adenocarcenoma

Postby Julia123 » Thu Nov 18, 2021 6:12 am

who is there with the same diagnosis? very scary
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now

JJH
Posts: 324
Joined: Mon Apr 24, 2017 7:26 am

Re: mucinous adenocarcinoma

Postby JJH » Fri Nov 19, 2021 5:47 am

Julia123 wrote:who is there with the same diagnosis? very scary

Some posts containing "mucinous adenocarcinoma"
"The darkest hour is just before the dawn" - Thomas Fuller (1650)

Julia123
Posts: 8
Joined: Sun Nov 07, 2021 4:00 pm

Re: mucinous adenocarcenoma

Postby Julia123 » Wed Dec 01, 2021 9:46 am

no survivor, very sad :(
04.06 (июнь) 2021 г.
Муцинозная аденокарцинома сигмовидного рака
(ICD-O-3: 8480/3)

pT3 pN1a (1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0,69

MMEp / MSS: MLH1 +, PMS2 +, MSH2 +, MSH6 +



09.06 расширенная резекция (с брюшной стенкой)

28.07 Folfox6 - 12 циклов

24.09 Магнитно-резонансная томография - очистить
Cea 2.2
1.12.2021 - 8 cycles done now


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