The Colon Club

good afternoon, i'm from ukraine, i'm 29 years old, diagnosed on June 4, mucinous adenocarcenoma 3b, now completed the 7th course folfox / 12 tell me who faced this type of tumor? what am I missing in treatment? Maybe I need some other medications and DNA tests? sorry for bad english

-———————————-
04.06(jun)2021
Mucinous adenocarcinoma sigmoid cancer
( ICD-O-3: 8480/3)

pT3 pN1a(1/36) M0 TD1 L0 V0 Pn0
CEA 2, CA19-9 0.69

MMEp/MSS: MLH1+, PMS2+,MSH2+, MSH6+



09.06 extended resection (with abdominal wall)

28.07 Folfox6 - 12 cycles

24.09 magnetic resonance tomography- clear
Cea 2.2
8.11.2021 - 7 cycles n

This link might be useful to you.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440160/

Its a subtype of Colon Cancer, Many people with Lynch Syndrome present I think with this. Its treated about the same as other Colon cancers, but might be a candidate for Checkpoint inhibitors due to its MSI status.

Good Luck

GrouseMan

You might be able to find some useful information here:

https://www.mskcc.org/russian

Julia123's signature indicated that she is MSS, not MSI.

boxhill wrote:Julia123's signature indicated that she is MSS, not MSI.

Hi,
does this mean that a mutation test is not needed? I understand that this is not Lynch syndrome.

Even though you are MSS you may still have mutations that significantly affect your treatment, so you should still get it. And, not to confuse the matter but important, if your tumor mutation burden is 12 or so, you may still be eligible for immunotherapy. In addition, there are trials going on that combine other drugs with immunotherapy.

From what I've read, this could be particularly important to those with mucinous tumors.

Julia123 wrote:

boxhill wrote:Julia123's signature indicated that she is MSS, not MSI.

Hi,
does this mean that a mutation test is not needed? I understand that this is not Lynch syndrome.

In my opinion, a mutation test is not really needed unless you are Stage IV. If you ever become Stage IV due to a recurrence, then a KRAS/NRAS/BRAF mutation panel is needed in order to determine which therapy regimens will be available to you. But you might want to have the test done now anyway, just to see what your status would be. Also, you may want to do a more extensive mutation test that will provide a Tumor Mutation Burden (TMB) index, if these kinds of test panels are available in your area.

In the USA, the following therapy drugs are available for use by colorectal cancer patients. However, the ones in bold face type below will require the KRAS/NRAS/BRAF mutation tests to see if you qualify for them. You would qualify for all the rest except the ones for 'MSI-H only'. You don't qualify for the 'MSI-H' drugs since your tumor is not MSI-H.

Drugs used in colorectal cancer, with ther FDA approval dates
1962 5-FU (Fluorouracil Injection) - no restrictions
1998 Xeloda (Capecitabine) - no restrictions
2000 Camptosar (Irinotecan Hydrochloride) - no restrictions
2004 Avastin (Bevacizumab) - mCRC 1st line+
2004 Eloxatin (Oxaliplatin) - no restrictions
2004 Erbitux (Cetuximab) - mCRC 1st line+, KRAS wild type only
2006 Vectibix (Panitumumab) - mCRC 1st line+, KRAS wild type only
2012 Keytruda (Pembrolizumab) - mCRC 1st line, MSI-H only
2012 Zaltrap (Ziv-Aflibercept) - mCRC 2nd line,
2012 Stivarga (Regorafenib) - no restrictions
2014 Cyramza (Ramucirumab) - mCRC 2nd line
2015 Lonsurf (Trifluridine and Tipiracil Hydrochloride) - no restrictions
2017 Opdivo (Nivolumab) - mCRC 1st line+, MSI-H only
2018 Yervoy (Ipilimumab) - mCRC 1st line+, MSI-H only
2019 Zirabev (Bevacizumab.alt) - mCRC 1st line+
2020 Braftovi (Encorafenib) - mCRC, BRAF V600E only

thank you very much for the answers! I am very worried about recurrence

Given that mucinous tumors don't typically respond well to conventional chemotherapy, genetic testing at an earlier stage seems wise to me. My oncologist has been having genetic testing done on all of his stage 3 patients for several years. It doesn't have to be Foundation One.

who is there with the same diagnosis? very scary

Julia123 wrote:who is there with the same diagnosis? very scary

Some posts containing "mucinous adenocarcinoma"

no survivor, very sad

Julia123 wrote:good afternoon, i'm from Ukraine, i'm 29 years old, diagnosed on June 4, mucinous adenocarcenoma 3b, now completed the 7th course folfox / 12 tell me who faced this type of tumor? what am I missing in treatment? Maybe I need some other medications and DNA tests? sorry for bad english

Hi Julia,

How are things going now? I saw that you logged in briefly just a couple days ago but you didn't leave any message.

I hope you and your family are OK.

Take care, and keep safe !

Echoing JJH’s concerns here. I hope you and yours are safe.

I'm sure we are all thinking of you at this terrible time. Who knows whether you can get or send messages, or more importantly get treatment, but you are in my thoughts and those of many others I am sure.