PCR for dMMR/MSI-H

[MadMed]

The number of pathological complete response is astounding for this clinical trial:
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(21)00348-4/fulltext

15 of 17 patients (88% [95% CI 64–99]) in the toripalimab plus celecoxib group and 11 of 17 patients (65% [38–86]) in the toripalimab monotherapy group had a pathological complete response

It's a small sample, but i have not seen that kind of response elsewhere. If you are MSI, you might get interested.

[catstaff]

It's consistent with emerging data that immunotherapy should probably be first-line treatment for MSI-H. I'm not sure whether the sample was large enough to say whether celecoxib added anything or not. They didn't seem to be comparing it to Folfox or such.

Now if only somebody could come up with a comparably effective treatment for the 95% of cases that are MSS. Maybe one of the bispecific antibodies in development will be useful for that.