The Colon Club

Hello

We are starting day 4 on the first cycle of Lonsurf. Last night Papa was hourly on the toilet. I am worried that something is wrong with the kidney. The oncologist warned us that the drug can cause the appearance of proteins in the urine.

Did anyone have something similar? If so did it go away or is it a bad sign?

Take care.

My husband has proteinuria from a different drug (bevacizumab, an anti-VEGF). I understand the mechanism there (a certain type of kidney cell requires VEGF to function) but not for Lonsurf so I'm not sure what they might do. For the anti-VEGFs if it progresses they just withhold the drug since, as his oncologist said, "nobody has done any studies about it." However, mild proteinuria wouldn't generally cause symptoms. Is the urine foamy? Does he have swelling in his hands or feet? Those would be symptoms of more severe kidney issues.

But mainly we can't diagnose anything, you need to have him checked by his oncologist.