Lonsurf on nightly toilet visits

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Joined: Sat May 15, 2021 12:53 pm

Lonsurf on nightly toilet visits

Postby Tueffel » Sat Oct 02, 2021 1:56 am


We are starting day 4 on the first cycle of Lonsurf. Last night Papa was hourly on the toilet. I am worried that something is wrong with the kidney. The oncologist warned us that the drug can cause the appearance of proteins in the urine.

Did anyone have something similar? If so did it go away or is it a bad sign?

Take care.
Papa *64
Has MS, 18/19 w Alemtuzumab
01/20 dx adeno
pT3, pN1c (0/13; deposits), pM1 liver
Pn1, R0, G2
Treated: Germany
4x folfox
05-06/20 liver + colon surgery
08-11/2020 folfox, 60% oxaliplatin
02/21 2nd liver surgery
04/21 recurrence
2 weeks: 50% growth
Since 05/21 5x TACE, 7x Folfiri + bev
08/21 still growth, ileus surgery and peritoneal mets,
10/21 Lonsurf Cyramza

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O Stoma Mia
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Re: Lonsurf on nightly toilet visits

Postby O Stoma Mia » Sat Oct 02, 2021 2:31 am

Posts: 165
Joined: Wed Mar 03, 2021 11:37 am

Re: Lonsurf on nightly toilet visits

Postby catstaff » Sat Oct 02, 2021 2:32 pm

My husband has proteinuria from a different drug (bevacizumab, an anti-VEGF). I understand the mechanism there (a certain type of kidney cell requires VEGF to function) but not for Lonsurf so I'm not sure what they might do. For the anti-VEGFs if it progresses they just withhold the drug since, as his oncologist said, "nobody has done any studies about it." However, mild proteinuria wouldn't generally cause symptoms. Is the urine foamy? Does he have swelling in his hands or feet? Those would be symptoms of more severe kidney issues.

But mainly we can't diagnose anything, you need to have him checked by his oncologist.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-

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