Anyone on trial NCT04426669?

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susanCT1
Posts: 8
Joined: Mon Sep 20, 2021 5:54 pm

Anyone on trial NCT04426669?

Postby susanCT1 » Wed Sep 22, 2021 5:03 pm

I haven't seen anyone mention about this trial, but just wondering if anyone was able to get on it and post any progress/update? It will be very helpful

NCT04426669
A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering
Wife to my DH
8/10: Dx 45 M, father of 2 boys(5 and 3), Greater Chicago region
Tumor location: left side, sigmoid colon, CEA 945
Stage 4, Colorectal Poorly differentiated Adenocarcinoma,
Mets: Lymph nodes Cervical, Chest, abdominal, pelvis

Biomarker: Tumor burden 2.1, MSS, KRAS/BRAF/NRAS wild, RAD51B, TP53, APC, ZNF217
Chemo: Folfoxiri+Avastin
9/13: 2nd CEA scan 1008

catstaff
Posts: 163
Joined: Wed Mar 03, 2021 11:37 am

Re: Anyone on trial NCT04426669?

Postby catstaff » Thu Sep 23, 2021 8:17 am

My husband isn't on it, but something I do when researching clinical trials is google the name of the PI (Principle Investigator) to see whether anything has been published about preliminary results, including preclinical studies. In this case, it appears that the PI is particularly interested in brain cancers and mets.

His twitter handle is "cancerassassin1" for what that may be worth.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis
FOLFIRI+bev 3/21-

User avatar
O Stoma Mia
Posts: 1672
Joined: Sat Jun 22, 2013 6:29 am

Re: Anyone on trial NCT04426669?

Postby O Stoma Mia » Sat Sep 25, 2021 3:49 am

susanCT1 wrote:I haven't seen anyone mention about this trial, but just wondering if anyone was able to get on it and post any progress/update? It will be very helpful

NCT04426669
A Study of Metastatic Gastrointestinal Cancers Treated With Tumor Infiltrating Lymphocytes in Which the Gene Encoding the Intracellular Immune Checkpoint CISH Is Inhibited Using CRISPR Genetic Engineering


sdino
Posts: 85
Joined: Tue Mar 28, 2017 5:32 pm

Re: Anyone on trial NCT04426669?

Postby sdino » Thu Sep 30, 2021 7:32 am

My wife was slated for this trial prior to her iTCR TIL trial in April 2019.. Her cells from NIH were sent to U. of Minnesota with our permission. But Dr Rosenberg @ NIH eluded they had some complications with the trial and shelved it for awhile. So she did two TIL trials @ NIH. Essentially it's the same Protocol as a TIL trial (NCT01174121), except they knock out the CRSPIR Gene that is potentially screwed up causing proliferation of bad cells, hence they remove the bad gene sequence, then..... introduce TILs with specific reactive neoantigens to attack those mutations.
Caregiver for Wife 54 yrs old
DX:11/16-CC sigmoid colon
Lung Mets: 25+ Bilateral ranging 4mm-5.0cm
MSS, KRAS-G12D; TP53
iTCR TIL Trial NCT03412877 4/19 to 7/19 Off trial, - Sept. 2019 TIL trial NCT01174121
CT Scans: 7/2020 lung met shrinkage 36%, 3 lung mets left, two Liver mets destroyed by TILs
Brain tumor removal 3/2020
CEA:16-11/16; 5 -9/18; 63 -8/19; 1 -1/20; 0.8-5/20


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