catstaff wrote:Did they have you on Folfiri+bev while your CEA was 2.5-3.5? May not be NED but seems pretty close to it. The BEACON regimen mentioned may be a viable option, but you may also want to reserve that for later. PET may be a good idea also.
Rikimaroo wrote:With that CEA i would ask for a break and keep and eye on things. I am on maintenance which is 5fu and Avastin. pulled out the Irinotecan. It's still tough. My last cea check was 21, but next one hopefully is down more. Getting CT scan this week, but I thing are stable so far.
catstaff wrote:Is that three more cycles after already 20? Seems like a lot if it's gotten your CEA so low (congratulations, by the way). My DH has done 12 and it's beaten him up, mostly due to anemia. He has two more scheduled, including one Monday. His CEA is still dropping though at a much slower rate than initially.
Nor Cal wrote:Thanks everyone for the replies. I've talked to my cancer team and family about this, but it's very valuable to get perspective from the patients/caregivers.
rp1954 wrote:The difficulty is achieving good chemo sensitivity post Folfiri with Xeloda alone. Even the ADAPT formula, Xeloda with Celebrex added had difficulty with successful post Folfiri application for a percentage of patients.
I do believe that there are a number of things that you could do to try to make Xeloda useful post Folfiri.
1. Chronomodulated xeloda may comfortably allow a higher daily dose, and an even higher peak dose and effect each day.
2. IV vitamin C is considered a possible adjunct for Kras mutant, and may combine synergistically with 5FU drugs and other mild chemistry and nutraceuticals. IVC did combine well for us, based on preclinical data, personal lab data for cytocidal tx of excised tissue, and then blood marker series.
IV vitamin C also has the potential benefit of elimination/reduction of Xeloda's Hand Foot Syndrome, a common limit to Xeloda tx.
3. The continuous maintenance of Xeloda, celecoxib and other residuals during chronomodulated tx may stop or slow met spread with 24 x 365 coverage with superior QoL.
4. We found that variations in immunochemo formula would cause lesions to dissolve or die in different places over time.
5. Nutraceuticals help the body recover from chemo; some can be inhibitory adjuncts in a cocktail.
JB09 wrote:Nor Cal wrote:Thanks everyone for the replies. I've talked to my cancer team and family about this, but it's very valuable to get perspective from the patients/caregivers.
Hey. My husband is BRAF v600e as well. It's a beast of a mutation. I'd love to talk more about your journey thus far. Finding this forum a little difficult to view comprehensive posts. Currently, he is on a very in-depth integrative protocol alongside Folfiri+Avastin. Inching towards maintenance. Where are you being treated? There at a lot of new trials out there. Many with various targeted and IO. I had high hopes for ERK1/2, however, the results aren't blowing me away. I have a friend starting the doublet+SHP2i. We don't have measurable tumors, so we don't qualify. Regardless, I am focused more on low dose chronomodulated chemo + supplements. Would love to connect.
Nor Cal wrote:JB09 wrote:Nor Cal wrote:Thanks everyone for the replies. I've talked to my cancer team and family about this, but it's very valuable to get perspective from the patients/caregivers.
Hey. My husband is BRAF v600e as well. It's a beast of a mutation. I'd love to talk more about your journey thus far. Finding this forum a little difficult to view comprehensive posts. Currently, he is on a very in-depth integrative protocol alongside Folfiri+Avastin. Inching towards maintenance. Where are you being treated? There at a lot of new trials out there. Many with various targeted and IO. I had high hopes for ERK1/2, however, the results aren't blowing me away. I have a friend starting the doublet+SHP2i. We don't have measurable tumors, so we don't qualify. Regardless, I am focused more on low dose chronomodulated chemo + supplements. Would love to connect.
I''m being treated at Enloe in Chico. 2nd opinions from UC Davis and Stanford. Right now we're waiting for my MRI results and will game plan from there. We've discussed xeloda along with potential things to add to that treatment. After 16 months on FOLFOXIRI/FOLFIRI I'd like to find something a bit more tolerable.
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