I don't have any experience with Vectibix since it's contraindicated for my husband (KRAS mutation, it is worse than useless for that) though I am aware that some members here have been on it off and on for a long time, perhaps not as monotherapy however. I just wanted to say that I'm surprised that anybody even suggested a possibility of a cure with such extensive distal LN spread. My husband had three distal nodes at diagnosis and they treated him sort of like a stage IIIC+ even though he was IV (but even a lot of IIIC patients relapse) so I was braced for a recurrence even though I hoped it wouldn't happen. Once it did I didn't have any illusions of a cure. (A very small fraction of patients are cured by chemo alone, I'm not discounting that, it's just unusual.) As I've said on other threads, I don't expect a true cure for any Stage IV cancer in my lifetime, certainly not in DH's. I am hoping for a long-term treatment, preferably with fewer side effects than what we have now, to arrive in time. GrouseMan said it might be "thousands" of diseases which, strictly speaking, is probably true, but I am optimistic that there are a handful of common pathways that could be attacked, at least for the most common cancers. So we may not need quite that level of personalized oncology.
All you can do is your best to try to keep the boat afloat as long as possible. Stable is good.
Last edited by catstaff
on Sat Sep 18, 2021 7:46 am, edited 1 time in total.
D/H Dx 10/2019 RC age 61
Clinical T4bN2M1a (common iliac and para-aortic lymph nodes)
MSS KRAS G12D
CRT 11/19-1/20 FOLFOX 3/20-7/20
Pelvic exenteration w/LAR 8/20
ypT4bN0Mx G3 0/14 nodes LVI not seen PNI-
CEA 10/19:20, 1/20-11/20:1.6, 4.3, 3.4, 2.7, 2/21:9.0 3/21:18,40 4/21:28,19, 5/21:13.3,8.6
PET 3/21 recurrence in distal nodes, L5 vertebra, pelvis